PMID- 37214574
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230523
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 11
IP  - 12
DP  - 2023 Apr 26
TI  - Analysis of oxidative stress and antioxidative potential in premature ovarian 
      insufficiency.
PG  - 2684-2693
LID - 10.12998/wjcc.v11.i12.2684 [doi]
AB  - BACKGROUND: Premature ovarian insufficiency (POI) is characterized by an early 
      decline in ovarian function, inducing secondary amenorrhea. While the cause of 
      POI has not yet been identified, the function of mitochondria in the ovaries and 
      the cytotoxicity associated with reactive oxygen species (ROS) have been 
      implicated in follicle pool depletion and a decline in follicle quality. Recently 
      developed tests have enabled easy measurement of diacron-reactive oxygen 
      metabolites (d-ROMs) and biological antioxidant potential (BAP). The combination 
      of these two tests is used to comprehensively assess oxidative stress in the 
      blood. AIM: To comprehensively assess the oxidative stress of d-ROMs and BAP in 
      POI. METHODS: Participants were classified into two groups: A POI group of 11 
      women aged < 40 years examined between January 2021 and June 2022 with a history 
      of secondary amenorrhea for at least 4 mo in our hospital and an FSH value of >/= 
      40 mIU/mL; and a control group of healthy women of the same age with normal 
      ovarian function in our hospital. Plasma d-ROMs and BAP were measured in both 
      these groups underwent. Differences between groups were assessed using the 
      t-test. RESULTS: The mean age and mean body mass index (BMI) were 35.8 +/- 3.0 
      years and 20.1 +/- 1.9 kg/m(2) in the control group and 35.8 +/- 2.7 years and 19.4 +/- 
      2.5 kg/m(2) in the POI group, respectively. The mean gravidity and parity in 
      control and POI groups were 0.6 +/- 0.7 and 0.4 +/- 0.5 and 0.6 +/- 0.9 and 0.3 +/- 0.5, 
      respectively. The two groups did not differ significantly in terms of mean age, 
      BMI, gravidity, or parity. The d-ROMs level was significantly higher in the POI 
      group than in the control group (478.2 +/- 58.7 vs 341.1 +/- 35.1 U.CARR; P < 0.001); 
      however, the BAP level did not significantly differ between the two groups 
      (2078.5 +/- 157.4 vs 2029.0 +/- 186.4 mumol/L). The oxidase stress index (d-ROMs/BAP x 
      100) was significantly higher in the POI group than in the control group (23.7 +/- 
      3.3 vs 16.5 +/- 2.1; P < 0.001). CONCLUSION: Oxidative stress was significantly 
      greater in the POI group than in the control group, suggesting oxidative stress 
      as a factor that can serve as a POI biomarker.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Kakinuma, Kaoru
AU  - Kakinuma K
AD  - Department of Obstetrics and Gynecology, International Health and Welfare 
      Hospital, Nasushiobara 327-2763, Japan.
FAU - Kakinuma, Toshiyuki
AU  - Kakinuma T
AD  - Department of Obstetrics and Gynecology, International Health and Welfare 
      Hospital, Nasushiobara 327-2763, Japan. tokakinuma@gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC10198121
OTO - NOTNLM
OT  - Antioxidant
OT  - Ovary
OT  - Oxidative stress
OT  - Premature ovarian insufficiency
OT  - Reactive oxygen species
COIS- Conflict-of-interest statement: All the Authors have no conflict of interest 
      related to the manuscript.
EDAT- 2023/05/22 19:11
MHDA- 2023/05/22 19:12
PMCR- 2023/04/26
CRDT- 2023/05/22 12:13
PHST- 2023/01/06 00:00 [received]
PHST- 2023/02/20 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/05/22 19:12 [medline]
PHST- 2023/05/22 19:11 [pubmed]
PHST- 2023/05/22 12:13 [entrez]
PHST- 2023/04/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v11.i12.2684 [doi]
PST - ppublish
SO  - World J Clin Cases. 2023 Apr 26;11(12):2684-2693. doi: 
      10.12998/wjcc.v11.i12.2684.