PMID- 3721555
OWN - NLM
STAT- MEDLINE
DCOM- 19860725
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 8
IP  - 6 Pt 2
DP  - 1986 Jun
TI  - Calcium-related abnormalities in lymphocytes from genetically hypertensive rats.
PG  - II123-6
AB  - We examined the effect of various external calcium concentrations on net 
      potassium efflux and net sodium influx in lymphocytes from spontaneously 
      hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHRSP), 
      and Wistar-Kyoto rats (WKY). Net potassium efflux was greater in lymphocytes from 
      SHRSP than in those from WKY at external calcium concentrations of 0.1, 0.3, 1.0, 
      and 3.0 mM but not at 0 mM (14.9 +/- 0.8 vs 13.0 +/- 0.7 mmol per kilogram of dry 
      weight per hour, respectively). Net sodium influx in lymphocytes from SHRSP was 
      greater than in those from WKY at all external calcium concentrations tested (0, 
      0.1, 1.0, and 3.0 mM). In contrast to lymphocytes from WKY, net potassium efflux 
      and net sodium influx in lymphocytes from SHRSP were not significantly higher at 
      0 than at 0.1 mM external calcium concentration. Lymphocytes from SHRSP had 
      elevated intracellular free calcium concentrations (173.6 +/- 7.4 nM, n = 8), as 
      compared with lymphocytes from WKY (98.1 +/- 9.1 nM, n = 8). These data suggest 
      that the interaction of calcium with the lymphocyte plasma membrane directly 
      affects monovalent ion permeability and is altered in lymphocytes from SHRSP, as 
      compared with those from WKY. Our findings support the hypothesis that in 
      hypertension there is a generalized increase in cell membrane permeability to 
      calcium and monovalent ions, which may result from a reduced number of 
      calcium-binding sites on the plasma membrane.
FAU - Furspan, P B
AU  - Furspan PB
FAU - Bohr, D F
AU  - Bohr DF
LA  - eng
GR  - 18575/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*blood/pharmacology
MH  - Cell Membrane Permeability
MH  - Female
MH  - Hypertension/*blood
MH  - In Vitro Techniques
MH  - Lymphocytes/*metabolism
MH  - Male
MH  - Muscle, Smooth, Vascular/metabolism
MH  - Potassium/blood
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Sodium/blood
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
AID - 10.1161/01.hyp.8.6_pt_2.ii123 [doi]
PST - ppublish
SO  - Hypertension. 1986 Jun;8(6 Pt 2):II123-6. doi: 10.1161/01.hyp.8.6_pt_2.ii123.