PMID- 37215877
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230523
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 5
DP  - 2023 May
TI  - Association between renal function and bone mineral density in patients with type 
      2 diabetes mellitus.
PG  - e15967
LID - 10.1016/j.heliyon.2023.e15967 [doi]
LID - e15967
AB  - BACKGROUND: This study evaluated the association between renal function, assessed 
      by serum creatinine and estimated glomerular filtration rate (eGFR) according to 
      the Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) 
      equations, and bone mineral density (BMD) in Chinese patients with type 2 
      diabetes mellitus (T2DM). METHODS: 1322 patients with T2DM were included, and 
      their basic clinical information, serum biochemical tests, and BMD at the total 
      hip and femur neck were collected. Multivariate adjusted linear regression, 
      smooth curve fitting and a piecewise linear regression model were used to analyze 
      linear and nonlinear associations. Age, BMI, drinking, smoking, systolic blood 
      pressure and diastolic blood pressure, FBG, HbA1C, course of diabetes, hsCRP, TC, 
      TG, HDL-C, LDL-C, Ca, P, PTH, ALP, OC, P1NP, beta-CTX and 25(OH)D were adjusted. 
      RESULTS: After adjusting the variables, no correlation between eGFR CG and eGFR 
      MDRD and femur neck BMD was observed in women, men, or the total population. The 
      eGFR CG and eGFR MDRD had a significant positive association with total hip BMD 
      in men and the total population with T2DM. With a 10-unit decrease in eGFR CG, 
      total hip BMD reduced by 0.012 g/cm(2) in men and 0.010 g/cm(2) the total 
      population. Total hip BMD reduced by 0.014 g/cm(2) in men and 0.022 g/cm(2) in 
      the total population with a 10-unit decrease in eGFR MDRD. There was no 
      correlation between eGFR CG or eGFR MDRD and total hip BMD in female 
      participants. CONCLUSION: Impaired renal function was associated with decreased 
      total hip BMD in men and the total population with T2DM. No associated between 
      renal function with femur neck BMD was observed.
CI  - (c) 2023 The Authors.
FAU - Ye, Yangli
AU  - Ye Y
AD  - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
FAU - Yi, Xilu
AU  - Yi X
AD  - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
AD  - Department of Endocrinology and Metabolism, Central Hospital of Songjiang 
      District, Shanghai, China.
FAU - Zhang, Yao
AU  - Zhang Y
AD  - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
AD  - Department of Infectious Disease, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
FAU - Xu, Guiping
AU  - Xu G
AD  - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
AD  - VIP Clinical Department, Fujian Provincial Hospital, Fuzhou, China.
FAU - Yu, Mingxiang
AU  - Yu M
AD  - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 
      China.
FAU - Qu, Xinhua
AU  - Qu X
AD  - Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230502
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10195895
OTO - NOTNLM
OT  - Bone mineral density
OT  - Estimated glomerular filtration rate
OT  - Renal function
OT  - Total hip
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper
EDAT- 2023/05/22 19:11
MHDA- 2023/05/22 19:12
PMCR- 2023/05/02
CRDT- 2023/05/22 12:31
PHST- 2022/06/07 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/05/22 19:12 [medline]
PHST- 2023/05/22 19:11 [pubmed]
PHST- 2023/05/22 12:31 [entrez]
PHST- 2023/05/02 00:00 [pmc-release]
AID - S2405-8440(23)03174-2 [pii]
AID - e15967 [pii]
AID - 10.1016/j.heliyon.2023.e15967 [doi]
PST - epublish
SO  - Heliyon. 2023 May 2;9(5):e15967. doi: 10.1016/j.heliyon.2023.e15967. eCollection 
      2023 May.