PMID- 37221823
OWN - NLM
STAT- MEDLINE
DCOM- 20230809
LR  - 20230809
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 42
IP  - 3
DP  - 2023 Sep
TI  - Electrophysiological effects of hyperbaric oxygen treatment on the healthy 
      retina.
PG  - 103-108
LID - 10.1080/15569527.2023.2217250 [doi]
AB  - PURPOSE: The study aimed to investigate the electrophysiological effects of 
      hyperbaric oxygen treatment (HBOT) on the retina after ten sessions in healthy 
      eyes. METHODS: This prospective, interventional study evaluated forty eyes of 
      twenty patients who were treated with HBOT of ten sessions with the diagnosis of 
      an extraocular health problem. All patients underwent a complete ophthalmologic 
      examination, including assessments of best-corrected visual acuity (BCVA), 
      slit-lamp and pupil-dilated fundus examinations, full-field electroretinography 
      (ffERG) measurements before and after HBOT within 24 h of the 10th session. The 
      ffERG was recorded according to the International Society for Clinical 
      Electrophysiology of Vision protocol using the RETI-port system. RESULTS: The 
      mean age of patients was 40.5 years ranging from 20 to 59 years. Thirteen 
      patients were administered HBOT for avascular necrosis, six patients for sudden 
      hearing loss, and one patient for chronic osteomyelitis of the vertebra. BCVA 
      acuity was 20/20 in all eyes. The mean spherical refractive was 0.56 dioptre (D), 
      and the mean cylindrical refractive error was 0.75 D. Dark-adapted b-wave 
      amplitude in 3.0 ERG was the only variable for the b-wave that showed a 
      statistically significant decrease (p = 0.017). The amplitude of the a-waves in 
      dark-adapted 10.0 ERG and light-adapted 3.0 ERG reduced significantly (p = 0.024, 
      p = 0.025). The amplitude of N 1-P 1 in light-adapted 30 Hz Flicker ERG also 
      demonstrated a statistically significant decrease (p = 0.011). Implicit times did 
      not differ significantly in any of the ffERG data (p > 0.05). CONCLUSIONS: HBOT 
      caused the deterioration of a-wave and b-wave amplitudes in ffERG after ten 
      treatment sessions. The results showed that photoreceptors were adversely 
      affected in the short term after HBOT treatment.
FAU - Demir, Nur
AU  - Demir N
AUID- ORCID: 0000-0003-0738-7212
AD  - Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Kayhan, Belma
AU  - Kayhan B
AUID- ORCID: 0000-0003-0748-6691
AD  - Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Sumen, Selin Gamze
AU  - Sumen SG
AUID- ORCID: 0000-0002-9845-1306
AD  - Underwater and Hyperbaric Medicine Department, Kartal Lutfi Kirdar Training and 
      Research Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Sonmez, Murat
AU  - Sonmez M
AUID- ORCID: 0000-0003-4231-7797
AD  - Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Tukenmez Dikmen, Nejla
AU  - Tukenmez Dikmen N
AUID- ORCID: 0000-0001-6767-6871
AD  - Ophthalmology Department, Sultan 2. Abdulhamid Han Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230601
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Oxygen
MH  - *Hyperbaric Oxygenation/adverse effects
MH  - Prospective Studies
MH  - Retina
MH  - Electroretinography/methods
OTO - NOTNLM
OT  - Electrophysiology
OT  - ffERG
OT  - healthy retina
OT  - hyperbaric oxygen
OT  - photoreceptors
EDAT- 2023/05/24 06:42
MHDA- 2023/08/09 06:43
CRDT- 2023/05/24 01:23
PHST- 2023/08/09 06:43 [medline]
PHST- 2023/05/24 06:42 [pubmed]
PHST- 2023/05/24 01:23 [entrez]
AID - 10.1080/15569527.2023.2217250 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2023 Sep;42(3):103-108. doi: 10.1080/15569527.2023.2217250. 
      Epub 2023 Jun 1.