PMID- 37223029
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230528
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Mendelian randomization indicates a causal contribution of type 2 diabetes to 
      retinal vein occlusion.
PG  - 1146185
LID - 10.3389/fendo.2023.1146185 [doi]
LID - 1146185
AB  - BACKGROUND: Retinal vein occlusion (RVO) is a common retinal vascular disease 
      that can cause severe visual impairment. Many observational studies have shown 
      that type 2 diabetes (T2DM) is associated with RVO, but it remains unknown if the 
      association is causal. The present study aimed to perform Mendelian randomization 
      (MR) analyses to evaluate the causal contribution of genetically predicted T2DM 
      to RVO. METHODS: We obtained summary-level data from a genome-wide association 
      study meta-analysis including 48,286 cases and 250,671 controls for T2DM and from 
      a genome wide association study of 372 cases and 182,573 controls in the FinnGen 
      project for RVO. To verify the robustness of the results, an independent 
      validation dataset for T2DM (12,931 cases and 57,196 controls) was used. In 
      addition to the main MR analysis using the inverse variance weighted (fixed 
      effect) approach, sensitivity analyses and multivariable MR adjusting for common 
      risk factors of RVO were conducted. RESULTS: Genetically predicted T2DM was found 
      to be causally associated with RVO risk (odds ratio (OR)=2.823, 95% confidence 
      interval (CI): 2.072-3.847, P=4.868x10(-11)). This association was supported by 
      sensitivity analyses using the weighted median (OR=2.415, 95% CI: 1.411-4.132, 
      P=1.294x10(-3)), weighted mode (OR=2.370, 95% CI: 1.321-4.252, P=5.159x10(-3)), 
      maximum likelihood (OR=2.871, 95% CI: 2.100-3.924, P=3.719x10(-11)), MR-PRESSO 
      (OR=2.823, 95% CI: 2.135-3.733, P=5.150x10(-10)), and MR-Egger (OR=2.441, 95% CI: 
      1.149-5.184, P=2.335x10(-2)) methods. In addition, this association persisted in 
      multivariable MR after accounting for common RVO risk factors (OR=1.748, 95% CI: 
      1.238-2.467, P=1.490x10(-3)). The MR analyses using the validation dataset 
      obtained consistent results. CONCLUSION: This study indicates that genetically 
      predicted T2DM may have a causal contribution to RVO. Future studies are required 
      to elucidate the underlying mechanisms.
CI  - Copyright (c) 2023 Huang.
FAU - Huang, Jian
AU  - Huang J
AD  - Clinical Laboratory Center, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20230508
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - *Retinal Vein Occlusion/etiology/genetics
MH  - Genome-Wide Association Study
MH  - Mendelian Randomization Analysis
MH  - Causality
PMC - PMC10200935
OTO - NOTNLM
OT  - Mendelian randomization
OT  - causal association
OT  - retinal vein occlusion
OT  - risk
OT  - type 2 diabetes
COIS- The author declares that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/24 13:09
MHDA- 2023/05/26 06:42
PMCR- 2023/01/01
CRDT- 2023/05/24 11:40
PHST- 2023/01/17 00:00 [received]
PHST- 2023/04/05 00:00 [accepted]
PHST- 2023/05/26 06:42 [medline]
PHST- 2023/05/24 13:09 [pubmed]
PHST- 2023/05/24 11:40 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1146185 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 May 8;14:1146185. doi: 
      10.3389/fendo.2023.1146185. eCollection 2023.