PMID- 37223050
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230528
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Efficacy and safety of traditional Chinese medicines combined with conventional 
      Western medicines in the treatment of type 2 diabetes mellitus: a network 
      meta-analysis of randomized controlled trials.
PG  - 1134297
LID - 10.3389/fendo.2023.1134297 [doi]
LID - 1134297
AB  - AIMS/HYPOTHESIS: Through a comprehensive analysis of the clinical randomized 
      controlled trials of traditional Chinese medicine (TCM) combined with 
      conventional western medicine (CWM) in treating type 2 diabetes(T2DM) in the past 
      ten years, the clinical efficacy and safety of different TCMs combined with CWM 
      were explored. This study aimed to provide specific suggestions for clinical 
      guidance on treating T2DM. METHODS: A literature search was conducted in CNKI, 
      WanFang, VIP, CBM, PubMed, Embase, and Web of Science. The search time was 
      limited from 2010 to the present time. The literature type was a controlled 
      clinical trial study of TCM combined with CWM intervention in treating T2DM. The 
      outcome indices of the efficacy evaluation included fasting blood glucose (FBG), 
      2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), 
      adverse reactions, and clinical efficacy. Stata 15 and RevMan 5.4 software were 
      used to conduct a network meta-analysis and a traditional meta-analysis. RESULTS: 
      The results showed that shenqi jiangtang granule combined with sulfonylurea, 
      shenqi jiangtang granules combined with metformin and jinlida granules combined 
      with insulin had significant effects on reductions in FBG, 2hPG and clinical 
      efficacy compared with western medicines alone, which included fasting blood 
      glucose [MD=-2.17, 95%CI=(-2.50, -1.85)], blood sugar at 2 hours after a meal 
      [MD=-1.94, 95%CI=(-2.23, -1.65)], and clinical curative effect [OR= 1.73, 
      95%CI=(0.59, 2.87)]. CONCLUSIONS: TCM combined with CWM has a very significant 
      effect on treating T2DM compared with CWM alone. According to the network 
      meta-analysis, the best intervention measures of different TCMs for different 
      outcome indicators were obtained. SYSTEMATIC REVIEW REGISTRATION: identifier 
      42022350372.
CI  - Copyright (c) 2023 Ma, Zhou, Zhang, Zhao, Yao, Tian and Li.
FAU - Ma, Kaile
AU  - Ma K
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Zhou, Lijuan
AU  - Zhou L
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Zhang, Yanjiao
AU  - Zhang Y
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Zhao, Jingyi
AU  - Zhao J
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Yao, Chensi
AU  - Yao C
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Tian, Chuanxi
AU  - Tian C
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
AD  - Beijing University of Chinese Medicine, Beijing, China.
FAU - Li, Min
AU  - Li M
AD  - Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
LA  - eng
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20230508
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Shenqi Jiangtang)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Medicine, Chinese Traditional
MH  - Network Meta-Analysis
MH  - Blood Glucose
MH  - Randomized Controlled Trials as Topic
PMC - PMC10200885
OTO - NOTNLM
OT  - conventional western medicine
OT  - meta-analysis
OT  - network meta-analysis
OT  - traditional Chinese medicine
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/24 13:09
MHDA- 2023/05/26 06:42
PMCR- 2023/01/01
CRDT- 2023/05/24 11:40
PHST- 2022/12/30 00:00 [received]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/05/26 06:42 [medline]
PHST- 2023/05/24 13:09 [pubmed]
PHST- 2023/05/24 11:40 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1134297 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 May 8;14:1134297. doi: 
      10.3389/fendo.2023.1134297. eCollection 2023.