PMID- 37224522
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231024
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 11
DP  - 2023 Oct 18
TI  - Type 2 Diabetes Mellitus and Periodontitis: Bidirectional Association in 
      Population-based 15-year Retrospective Cohorts.
PG  - e1289-e1297
LID - 10.1210/clinem/dgad287 [doi]
AB  - OBJECTIVE: A two-way relationship between periodontitis and diabetes has been 
      proposed. However, bidirectional epidemiological observation is limited and 
      inconsistent. OBJECTIVE: Using the National Health Insurance Research Database of 
      Taiwan (covering over 99% of the entire population), we aimed to estimate the 
      development of diabetes in periodontitis patients or that of periodontitis in 
      patients with type 2 diabetes mellitus (T2DM), respectively. METHODS: A total of 
      11 011 patients with severe periodontitis were recruited from 2000 to 2015. After 
      matching by age, sex, and index date, 11 011 patients with mild periodontitis and 
      11 011 non-periodontitis controls were registered. Additionally, 157 798 patients 
      with T2DM and 157 798 non-T2DM controls were enrolled, in whom the development of 
      periodontitis was traced. Cox proportional hazards model was performed. RESULTS: 
      Periodontitis patients tended to have a statistically high risk for T2DM. The 
      adjusted hazard ratio was 1.94 (95% CI, 1.49-2.63, P < .01) and 1.72 (95% CI, 
      1.24-2.52, P < .01) for severe and mild periodontitis groups, respectively. The 
      patients with severe periodontitis had a higher risk of having T2DM relative to 
      those with mild periodontitis (1.17 [95% CI, 1.04-1.26, P < .001]). Conversely, 
      the risk of periodontitis increased significantly in patients with T2DM (1.99 
      [95% CI, 1.42-2.48, P < .01]). However, high risk was observed for the outcome of 
      severe periodontitis (2.08 [95% CI, 1.50-2.66, P < .001]), but not for mild 
      periodontitis (0.97 [95% CI, 0.38-1.57, P = .462]). CONCLUSION: We suggest that 
      the bidirectional association is between T2DM and severe but not mild 
      periodontitis.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Chien, Wu-Chien
AU  - Chien WC
AD  - Department of Medical Research, Tri-Service General Hospital, National Defense 
      Medical Center, Taipei 11490, Taiwan, ROC.
AD  - School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan, 
      ROC.
FAU - Fu, Earl
AU  - Fu E
AUID- ORCID: 0000-0003-0637-0208
AD  - Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, Xindian, New Taipei City 23142, Taiwan, ROC.
AD  - Department of Dentistry, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei 11490, Taiwan, ROC.
FAU - Chung, Chi-Hsiang
AU  - Chung CH
AD  - Department of Medical Research, Tri-Service General Hospital, National Defense 
      Medical Center, Taipei 11490, Taiwan, ROC.
AD  - School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan, 
      ROC.
FAU - Cheng, Chia-Mao
AU  - Cheng CM
AD  - Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, Xindian, New Taipei City 23142, Taiwan, ROC.
FAU - Tu, Hsiao-Pei
AU  - Tu HP
AD  - Department of Oral Hygiene, Hsin-Sheng Junior College of Medical Care and 
      Management, Taoyuan City 32544, Taiwan, ROC.
FAU - Lee, Wei-Cheng
AU  - Lee WC
AD  - Department of Medical Research, Tri-Service General Hospital, National Defense 
      Medical Center, Taipei 11490, Taiwan, ROC.
FAU - Chen, Wei-Liang
AU  - Chen WL
AUID- ORCID: 0000-0003-0784-230X
AD  - Department of Family and Community Medicine, Tri-Service General Hospital, 
      National Defense Medical Center, Taipei 11490, Taiwan, ROC.
AD  - School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan, ROC.
FAU - Shih, Kuang-Chung
AU  - Shih KC
AUID- ORCID: 0000-0003-1223-8350
AD  - School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan, ROC.
AD  - Division of Endocrinology & Metabolism, Tri-Service General Hospital, National 
      Defense Medical Center, Taipei 11490, Taiwan, ROC.
AD  - Division of Endocrinology & Metabolism, Cheng Hsin General Hospital, Taipei 
      11220, Taiwan, ROC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Retrospective Studies
MH  - *Periodontitis/complications/epidemiology
MH  - Taiwan/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - database
OT  - diabetes mellitus
OT  - national health programs
OT  - periodontitis
EDAT- 2023/05/24 19:13
MHDA- 2023/10/23 00:43
CRDT- 2023/05/24 17:13
PHST- 2023/01/13 00:00 [received]
PHST- 2023/10/23 00:43 [medline]
PHST- 2023/05/24 19:13 [pubmed]
PHST- 2023/05/24 17:13 [entrez]
AID - 7177560 [pii]
AID - 10.1210/clinem/dgad287 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Oct 18;108(11):e1289-e1297. doi: 
      10.1210/clinem/dgad287.