PMID- 37226250
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230527
IS  - 1749-799X (Electronic)
IS  - 1749-799X (Linking)
VI  - 18
IP  - 1
DP  - 2023 May 24
TI  - Effect of omega-3 polyunsaturated fatty acids supplementation for patients with 
      osteoarthritis: a meta-analysis.
PG  - 381
LID - 10.1186/s13018-023-03855-w [doi]
LID - 381
AB  - BACKGROUND: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) confers 
      anti-inflammatory efficacy, which has been suggested to be effective for patients 
      with osteoarthritis (OA). However, previous studies evaluating the influence of 
      n-3 PUFAs supplementation in patients with OA showed inconsistent results. We 
      performed a systematic review and meta-analysis to comprehensively evaluate the 
      influence of n-3 PUFAs on symptom and joint function of patients with OA. 
      METHODS: Relevant randomized controlled trials (RCTs) were obtained by searching 
      PubMed, Embase, and Cochrane Library databases. A random-effects model was 
      employed to combine the results. RESULTS: Nine RCTs with 2070 patients with OA 
      contributed to the meta-analysis. Pooled results showed that n-3 PUFAs 
      supplementation could significantly relieve the arthritis pain as compared to 
      placebo (standardized mean difference [SMD]: - 0.29, 95% confidence interval [CI] 
      - 0.47 to - 0.11, p = 0.002, I(2) = 60%). Besides, supplementation with n-3 PUFAs 
      was also associated with improved joint function (SMD: - 0.21, 95% CI - 0.34 to 
      - 0.07, p = 0.002, I(2) = 27%). Subgroup analysis showed consistent results of 
      studies with arthritis pain and joint function evaluated by the Western 
      Ontario-McMaster University Osteoarthritis Index and other scales (p for subgroup 
      difference = 0.33 and 0.34, respectively). No severe treatment-related adverse 
      events (AEs) were observed in the included patients, and the incidence of overall 
      AEs was similar between groups (odds ratio: 0.97, 95% CI 0.64-1.45, p = 0.86, 
      I(2) = 0%). CONCLUSIONS: Supplementation of n-3 PUFAs is effective to relieve 
      pain and improve joint function in patients with OA.
CI  - (c) 2023. The Author(s).
FAU - Deng, Wen
AU  - Deng W
AD  - Medical Affairs Office, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Yi, Zhiqian
AU  - Yi Z
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Yin, Enzhi
AU  - Yin E
AD  - Department of Traumatology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Jie Fang Avenue 1095, Wuhan, 430030, China.
FAU - Lu, Rui
AU  - Lu R
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - You, Hongbo
AU  - You H
AD  - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China.
FAU - Yuan, Xuefeng
AU  - Yuan X
AD  - Department of Traumatology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Jie Fang Avenue 1095, Wuhan, 430030, China. 
      yxf@tjh.tjmu.edu.cn.
LA  - eng
GR  - NO.ZRMS2021000624/Natural Science Foundation of Hubei Province/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230524
PL  - England
TA  - J Orthop Surg Res
JT  - Journal of orthopaedic surgery and research
JID - 101265112
RN  - 0 (Fatty Acids, Unsaturated)
SB  - IM
MH  - Humans
MH  - Databases, Factual
MH  - *Osteoarthritis/drug therapy
MH  - Pain
MH  - Fatty Acids, Unsaturated
MH  - Dietary Supplements
PMC - PMC10210278
OTO - NOTNLM
OT  - Arthritis pain
OT  - Joint function
OT  - Meta-analysis
OT  - Omega-3 polyunsaturated fatty acids
OT  - Osteoarthritis
COIS- The authors declare that they have no competing interests.
EDAT- 2023/05/25 01:07
MHDA- 2023/05/26 06:42
PMCR- 2023/05/24
CRDT- 2023/05/24 23:53
PHST- 2023/03/21 00:00 [received]
PHST- 2023/05/13 00:00 [accepted]
PHST- 2023/05/26 06:42 [medline]
PHST- 2023/05/25 01:07 [pubmed]
PHST- 2023/05/24 23:53 [entrez]
PHST- 2023/05/24 00:00 [pmc-release]
AID - 10.1186/s13018-023-03855-w [pii]
AID - 3855 [pii]
AID - 10.1186/s13018-023-03855-w [doi]
PST - epublish
SO  - J Orthop Surg Res. 2023 May 24;18(1):381. doi: 10.1186/s13018-023-03855-w.