PMID- 37227421 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230528 IS - 2045-7022 (Print) IS - 2045-7022 (Electronic) IS - 2045-7022 (Linking) VI - 13 IP - 5 DP - 2023 May TI - The minimal clinically important difference of app-based electronic patient-reported outcomes for hay fever. PG - e12244 LID - 10.1002/clt2.12244 [doi] LID - e12244 AB - BACKGROUND: Hay fever is a common allergic disease, with an estimated worldwide prevalence of 14.4% and a variety of symptoms. This study assessed the minimal clinically important difference (MCID) of nasal symptom score (NSS), non-nasal symptom score (NNSS), and total symptoms score (TSS) for app-based hay-fever monitoring. METHODS: MCIDs were calculated based on the data from a previous large-scale, crowdsourced, cross-sectional study using AllerSearch, an in-house smartphone application. MCIDs were determined with anchor-based and distribution-based methods. The face scale score of the Japanese Allergic Conjunctival Disease Standard Quality of Life Questionnaire Domain III and the daily stress level due to hay fever were used as anchors for determining MCIDs. The MCID estimates were summarized as MCID ranges. RESULTS: A total of 7590 participants were included in the analysis (mean age: 35.3 years, 57.1% women). The anchor-based method produced a range of MCID values (median, interquartile range) for NSS (2.0, 1.5-2.1), NNSS (1.0, 0.9-1.2), and TSS (2.9, 2.4-3.3). The distribution-based method produced two MCIDs (based on half a standard deviation, based on a standard error of measurement) for NSS (2.0, 1.8), NNSS (1.3, 1.2), and TSS (3.0, 2.3). The final suggested MCID ranges for NSS, NNSS, and TSS were 1.8-2.1, 1.2-1.3, and 2.4-3.3, respectively. CONCLUSIONS: MCID ranges for app-based hay-fever symptom assessment were obtained from the data collected through a smartphone application, AllerSearch. These estimates may be useful for monitoring the subjective symptoms of Japanese patients with hay fever through mobile platforms. CI - (c) 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. FAU - Nagino, Ken AU - Nagino K AUID- ORCID: 0000-0002-0317-6074 AD - Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Sung, Jaemyoung AU - Sung J AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - University of South Florida, Morsani College of Medicine, Tampa, Florida, USA. FAU - Midorikawa-Inomata, Akie AU - Midorikawa-Inomata A AD - Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Eguchi, Atsuko AU - Eguchi A AD - Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Fujimoto, Keiichi AU - Fujimoto K AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Okumura, Yuichi AU - Okumura Y AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Yee, Alan AU - Yee A AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Fujio, Kenta AU - Fujio K AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Akasaki, Yasutsugu AU - Akasaki Y AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Huang, Tianxiang AU - Huang T AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Miura, Maria AU - Miura M AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Hurramhon, Shokirova AU - Hurramhon S AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Hirosawa, Kunihiko AU - Hirosawa K AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Ohno, Mizu AU - Ohno M AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Morooka, Yuki AU - Morooka Y AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Kobayashi, Hiroyuki AU - Kobayashi H AD - Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan. FAU - Inomata, Takenori AU - Inomata T AUID- ORCID: 0000-0003-3435-1055 AD - Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. AD - Juntendo University Graduate School of Medicine, AI Incubation Farm, Tokyo, Japan. LA - eng GR - OTC Self-Medication Promotion Foundation 2019 and 2021/ GR - The Institute for Environmental & Gender-specific Medicine, Juntendo University/ GR - Takeda Science Foundation/ GR - The Kondou Kinen Medical Foundation, Medical Research Encouragement Prize 2020/ GR - JP19ek0410063/Japan Agency for Medical Research and Development/ GR - JP23ek0410090/Japan Agency for Medical Research and Development/ GR - 20KK0207/Japan Society for the Promotion of Science/ GR - 21K17311/Japan Society for the Promotion of Science/ GR - 21K20998/Japan Society for the Promotion of Science/ GR - 22K16983/Japan Society for the Promotion of Science/ GR - The Ichiro Kanehara Foundation/ PT - Journal Article PL - England TA - Clin Transl Allergy JT - Clinical and translational allergy JID - 101576043 PMC - PMC10151605 OTO - NOTNLM OT - hay fever OT - minimal clinically important difference OT - mobile health OT - patient-reported outcome measures OT - pollen allergy COIS- The AllerSearch application was created using Apple's ResearchKit (Cupertino, CA, USA). Takenori Inomata, Yuichi Okumura, and Akie Midorikawa-Inomata are the owners of InnoJin, Inc., Tokyo, Japan, which developed AllerSearch. Takenori Inomata report receiving grants from Johnson & Johnson Vision Care, SEED Co., Ltd., Novartis Pharma K.K., and Kowa Company, Ltd., outside the submitted work, as well as personal fees from Santen Pharmaceutical Co., Ltd., and InnoJin, Inc. Ken Nagino, Yuichi Okumura., and Akie Midorikawa-Inomata received personal fees from InnoJin, Inc. outside the submitted work. The remaining authors declare no competing interests. EDAT- 2023/05/25 13:07 MHDA- 2023/05/25 13:08 PMCR- 2023/05/01 CRDT- 2023/05/25 10:43 PHST- 2023/03/06 00:00 [revised] PHST- 2022/12/02 00:00 [received] PHST- 2023/04/03 00:00 [accepted] PHST- 2023/05/25 13:08 [medline] PHST- 2023/05/25 13:07 [pubmed] PHST- 2023/05/25 10:43 [entrez] PHST- 2023/05/01 00:00 [pmc-release] AID - CLT212244 [pii] AID - 10.1002/clt2.12244 [doi] PST - ppublish SO - Clin Transl Allergy. 2023 May;13(5):e12244. doi: 10.1002/clt2.12244.