PMID- 37227867
OWN - NLM
STAT- MEDLINE
DCOM- 20231108
LR  - 20231112
IS  - 1559-0488 (Electronic)
IS  - 1559-047X (Linking)
VI  - 44
IP  - 6
DP  - 2023 Nov 2
TI  - Use of Cultured Epithelial Autograft in Conjunction with Biodegradable 
      Temporizing Matrix in Massive Burns: A Case Series.
PG  - 1434-1439
LID - 10.1093/jbcr/irad076 [doi]
AB  - Intensive care for massively burn patients has increased survival and highlights 
      the need for a solution to the problem of insufficient donor sites for autologous 
      skin coverage. In this case series, we present 10 patients with average burn size 
      of 81% TBSA and mean age of 24 years old, who underwent burn excision followed by 
      either immediate or delayed biodegradable temporizing matrix (BTM) placement. 
      After an integration period, the BTM was delaminated either the day before or 
      immediately prior to placement of cultured epithelial autografts over a widely 
      meshed (4:1 or 6:1) split thickness skin graft. One patient had cultured 
      epithelial autografts alone, without split thickness skin graft, placed on 
      integrated BTM and had successful take. Seven patients survived to discharge and 
      had average 95% wound closure at 135 +/- 35 days. The patients had on average 10.4 
      total operations and 8.7 excision and grafting operations. Five patients had 
      complications related to the BTM requiring removal or replacement including three 
      fungal infections, one bacterial infection and one with bleeding and a large clot 
      burden. In conclusion, this surgical strategy is a viable option for patients 
      with massive burns and insufficient donor for autologous skin grafting.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      American Burn Association. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Heard, Jason
AU  - Heard J
AD  - Burn Division, Department of Surgery, University of California Davis, Sacramento, 
      CA, USA.
FAU - Sen, Soman
AU  - Sen S
AD  - Burn Division, Department of Surgery, University of California Davis, Sacramento, 
      CA, USA.
FAU - Greenhalgh, David
AU  - Greenhalgh D
AUID- ORCID: 0000-0001-9998-8714
AD  - Burn Division, Department of Surgery, University of California Davis, Sacramento, 
      CA, USA.
FAU - Palmieri, Tina
AU  - Palmieri T
AUID- ORCID: 0000-0001-6340-1715
AD  - Burn Division, Department of Surgery, University of California Davis, Sacramento, 
      CA, USA.
FAU - Romanowski, Kathleen
AU  - Romanowski K
AUID- ORCID: 0000-0002-4431-2423
AD  - Burn Division, Department of Surgery, University of California Davis, Sacramento, 
      CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Burn Care Res
JT  - Journal of burn care & research : official publication of the American Burn 
      Association
JID - 101262774
SB  - IM
MH  - Humans
MH  - Young Adult
MH  - Adult
MH  - *Burns/surgery
MH  - Autografts/surgery
MH  - Transplantation, Autologous
MH  - Skin
MH  - Skin Transplantation
EDAT- 2023/05/25 19:12
MHDA- 2023/11/08 06:42
CRDT- 2023/05/25 12:44
PHST- 2023/11/08 06:42 [medline]
PHST- 2023/05/25 19:12 [pubmed]
PHST- 2023/05/25 12:44 [entrez]
AID - 7179683 [pii]
AID - 10.1093/jbcr/irad076 [doi]
PST - ppublish
SO  - J Burn Care Res. 2023 Nov 2;44(6):1434-1439. doi: 10.1093/jbcr/irad076.