PMID- 37229325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230528
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 25
IP  - 6
DP  - 2023 Jun
TI  - Efficacy and safety of covered versus uncovered self‑expandable metal stents for 
      the palliative treatment of malignant distal biliary stricture: A long‑term 
      retrospective study.
PG  - 297
LID - 10.3892/etm.2023.11996 [doi]
LID - 297
AB  - Both covered self-expandable metal stents (CSEMSs) and uncovered self-expandable 
      metal stents (USEMSs) have been tried in the palliation of malignant distal 
      biliary strictures by means of endoscopic retrograde cholangiopancreatography 
      (ERCP); however, the comparison of efficacy and safety between them remains 
      contested. To the best of our knowledge, no similar studies have assessed this in 
      the Chinese population. In the present study, the clinical and endoscopic data of 
      238 patients (CSEMSs, n=55; USEMSs, n=183) with malignant distal biliary 
      strictures from 2014 to 2019 were collected. The efficacy indicated by mean stent 
      patency, stent patency rate, mean patient survival time and survival rate, and 
      the safety indicated by adverse events after CSEMS or USEMS placement were 
      retrospectively analyzed and compared. The mean stent patency time was 
      significantly longer in the CSEMSs group than that in the USEMSs group 
      (262.8+/-195.3 days vs. 169.5+/-155.7 days, P=0.002). The mean patient survival time 
      was significantly longer in the CSEMSs group than that in the USEMSs group 
      (273.9+/-197.6 days vs. 184.9+/-167.6 days, P=0.003). The stent patency rate and 
      patient survival rate were significantly higher in the CSEMSs group than those in 
      the USEMSs group at 6 and 12 months, but not at 1 and 3 months. There was no 
      significant difference in stent dysfunction and adverse events between the two 
      groups, although post-ERCP pancreatitis (PEP) occurred more frequently in the 
      CSEMSs group than in the USEMSs group (18.1% vs. 8.8%, P=0.049). In conclusion, 
      CSEMSs were better than USEMSs for malignant distal biliary strictures in terms 
      of stent patency time and patient survival time as well as stent patency rate and 
      patient survival rate in the long term (>6 months). Adverse events in the two 
      groups occurred at a similar rate, although the incidence of PEP was higher in 
      the CSEMSs group.
CI  - Copyright: (c) Zhu et al.
FAU - Zhu, Liang
AU  - Zhu L
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
AD  - Jiangxi Clinical Research Center for Gastroenterology, The First Affiliated 
      Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Wang, Zhenwen
AU  - Wang Z
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Huang, Zhiquan
AU  - Huang Z
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Yang, Xueping
AU  - Yang X
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Yu, Zhengping
AU  - Yu Z
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Cao, Ronglai
AU  - Cao R
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
FAU - Chen, Youxiang
AU  - Chen Y
AD  - Department of Gastroenterology, The First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, P.R. China.
AD  - Jiangxi Clinical Research Center for Gastroenterology, The First Affiliated 
      Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230505
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC10203749
OTO - NOTNLM
OT  - covered self-expandable metal stents
OT  - efficacy
OT  - malignant distal biliary stricture
OT  - safety
OT  - uncovered self-expandable metal stents
COIS- The authors declare that they have no competing interests.
EDAT- 2023/05/25 19:12
MHDA- 2023/05/25 19:13
PMCR- 2023/05/05
CRDT- 2023/05/25 14:22
PHST- 2022/09/16 00:00 [received]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/05/25 19:13 [medline]
PHST- 2023/05/25 19:12 [pubmed]
PHST- 2023/05/25 14:22 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - ETM-25-6-11996 [pii]
AID - 10.3892/etm.2023.11996 [doi]
PST - epublish
SO  - Exp Ther Med. 2023 May 5;25(6):297. doi: 10.3892/etm.2023.11996. eCollection 2023 
      Jun.