PMID- 37230291
OWN - NLM
STAT- MEDLINE
DCOM- 20230613
LR  - 20230614
IS  - 1873-6246 (Electronic)
IS  - 0301-0511 (Linking)
VI  - 180
DP  - 2023 May
TI  - Subtypes of insomnia revealed by the heterogeneity of neuroanatomical patterns: A 
      structural MRI study.
PG  - 108591
LID - S0301-0511(23)00108-4 [pii]
LID - 10.1016/j.biopsycho.2023.108591 [doi]
AB  - The current conflicting neuroimaging findings of insomnia disorder (ID) may be 
      attributed to heterogeneity in ID. The present study aims to clarify the high 
      heterogeneity in ID and examine the objective neurobiological subtypes of ID by 
      using a novel machine learning method based on gray matter volumes (GMVs). We 
      recruited 56 patients with ID and 73 healthy controls (HCs). The T1-weighted 
      anatomical images were obtained for each participant. We investigated whether the 
      ID has higher interindividual heterogeneity in GMVs. Then, we used a 
      heterogeneous machine learning algorithm by discriminative analysis (HYDRA) to 
      identify subtypes of ID with features of brain regional GMVs. We found that 
      patients with ID have higher interindividual variability than HCs. HYDRA 
      identified two distinct and reliable neuroanatomical subtypes of ID. Two subtypes 
      showed significantly different aberrance in GMVs compared with HCs. Specifically, 
      subtype 1 exhibited widespread decreased GMVs in some brain regions, including 
      the right inferior temporal gyrus, left superior temporal gyrus, left precuneus, 
      right middle cingulate, and right supplementary motor area. Subtype 2 only 
      demonstrated increased GMVs in the right superior temporal gyrus. Additionally, 
      the GMVs of altered brain regions in subtype 1 were significantly correlated with 
      daytime functioning, but in subtype 2, they were significantly correlated with 
      sleep disturbance. These results explain conflicting neuroimaging findings and 
      propose a potential objective neurobiological classification contributing to ID's 
      precise clinical diagnosis and treatment.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Zhang, Haobo
AU  - Zhang H
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China.
FAU - Sun, Haonan
AU  - Sun H
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China.
FAU - Li, Jiaqi
AU  - Li J
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China.
FAU - Fan, Yuhan
AU  - Fan Y
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China.
FAU - Julich, Simon Theodor
AU  - Julich ST
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China.
FAU - Lei, Xu
AU  - Lei X
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest 
      University), Ministry of Education, Chongqing 400715, China. Electronic address: 
      xlei@swu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230524
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
SB  - IM
MH  - Humans
MH  - *Sleep Initiation and Maintenance Disorders/diagnostic imaging
MH  - Brain/diagnostic imaging
MH  - Gray Matter/diagnostic imaging
MH  - Magnetic Resonance Imaging/methods
MH  - *Motor Cortex
OTO - NOTNLM
OT  - Gray matter volume
OT  - Heterogeneity
OT  - Insomnia
OT  - Machine learning
OT  - Subtypes
COIS- Declaration of Competing Interest All authors declare that they have no conflict 
      of interest. All authors approved the final version of the paper for submission.
EDAT- 2023/05/26 01:05
MHDA- 2023/06/13 06:42
CRDT- 2023/05/25 19:26
PHST- 2023/03/24 00:00 [received]
PHST- 2023/05/17 00:00 [revised]
PHST- 2023/05/22 00:00 [accepted]
PHST- 2023/06/13 06:42 [medline]
PHST- 2023/05/26 01:05 [pubmed]
PHST- 2023/05/25 19:26 [entrez]
AID - S0301-0511(23)00108-4 [pii]
AID - 10.1016/j.biopsycho.2023.108591 [doi]
PST - ppublish
SO  - Biol Psychol. 2023 May;180:108591. doi: 10.1016/j.biopsycho.2023.108591. Epub 
      2023 May 24.