PMID- 37231825
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240325
IS  - 1421-9786 (Electronic)
IS  - 1015-9770 (Linking)
VI  - 53
IP  - 1
DP  - 2024
TI  - Development and Validation of a Prediction Model for 30-Day Mortality and 
      Functional Outcome in Patients with Primary Brainstem Hemorrhage.
PG  - 79-87
LID - 10.1159/000530348 [doi]
AB  - INTRODUCTION: Primary brainstem hemorrhage (PBSH) is the most fatal subtype of 
      intracerebral hemorrhage and is associated with poor prognosis. We aimed to 
      develop a prediction model for predicting 30-day mortality and functional outcome 
      in patients with PBSH. METHODS: We reviewed records of 642 consecutive patients 
      with first-time PBSH from three hospitals between 2016 and 2021. Multivariate 
      logistic regression was used to establish a nomogram in a training cohort. Cutoff 
      points of the variables were determined by receiver operating characteristic 
      curve analysis, and certain points were assigned to these predictors to produce 
      the PBSH score. The nomogram and PBSH score were compared with other scoring 
      systems for PBSH. RESULTS: Five independent predictors, comprised of temperature, 
      pupillary light reflex, platelet-to-lymphocyte ratio, Glasgow Coma Scale (GCS) 
      score on admission, and hematoma volume, were incorporated to construct the 
      nomogram. The PBSH score consisted of 4 independent factors with individual 
      points assigned as follows: temperature, >/=38 degrees C (=1 point), <38 degrees C (=0 points); 
      pupillary light reflex, absence (=1 point), presence (=0 points); GCS score 3-4 
      (=2 points), 5-11 (=1 point), and 12-15 (=0 points); PBSH volume >10 mL (=2 
      points), 5-10 mL (=1 point), and <5 mL (=0 points). Results showed that the 
      nomogram was discriminative in predicting both 30-day mortality (area under the 
      ROC curve [AUC] of 0.924 in the training cohort, and 0.931 in the validation 
      cohort) and 30-day functional outcome (AUC of 0.887). The PBSH score was 
      discriminative in predicting both 30-day mortality (AUC of 0.923 in the training 
      cohort and 0.923 in the validation cohort) and 30-day functional outcome (AUC of 
      0.887). The prediction performances of the nomogram and the PBSH score were 
      superior to the intracranial hemorrhage (ICH) score, primary pontine hemorrhage 
      (PPH) score, and new PPH score. CONCLUSIONS: We developed and validated two 
      prediction models for 30-day mortality and functional outcome in patients with 
      PBSH. The nomogram and PBSH score could predict 30-day mortality and functional 
      outcome in PBSH patients.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Cai, Chengwei
AU  - Cai C
AD  - Department of Neurosurgery, The First Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
FAU - Yan, Chuangnan
AU  - Yan C
AD  - Department of Neurosurgery, The First Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
FAU - Chen, Shuxin
AU  - Chen S
AD  - Department of Neurosurgery, The First Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
FAU - Yang, Wenpeng
AU  - Yang W
AD  - Department of Neurosurgery, The Second Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
FAU - Huang, Yiping
AU  - Huang Y
AD  - Department of Neurosurgery, Jieyang People's Hospital, Jieyang, China.
FAU - Ma, Junqiang
AU  - Ma J
AD  - Department of Neurosurgery, The First Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
FAU - Xu, Hongwu
AU  - Xu H
AD  - Department of Neurosurgery, The First Affiliated Hospital of Shantou University 
      Medical College, Jieyang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230525
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
SB  - IM
MH  - Humans
MH  - *Cerebral Hemorrhage/diagnosis/therapy
MH  - *Intracranial Hemorrhages/diagnosis/therapy
MH  - ROC Curve
MH  - Nomograms
MH  - Retrospective Studies
MH  - Brain Stem
MH  - Prognosis
OTO - NOTNLM
OT  - Grading scale
OT  - Mortality and functional outcome
OT  - Nomogram
OT  - Primary brainstem hemorrhage
OT  - Prognosis
EDAT- 2023/05/26 06:42
MHDA- 2024/02/09 06:43
CRDT- 2023/05/26 03:46
PHST- 2023/02/02 00:00 [received]
PHST- 2023/03/13 00:00 [accepted]
PHST- 2024/02/09 06:43 [medline]
PHST- 2023/05/26 06:42 [pubmed]
PHST- 2023/05/26 03:46 [entrez]
AID - 000530348 [pii]
AID - 10.1159/000530348 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2024;53(1):79-87. doi: 10.1159/000530348. Epub 2023 May 25.