PMID- 37232081
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20231116
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 153
IP  - 5
DP  - 2023 Sep 1
TI  - Confounded association between proton pump inhibitor use and risk of biliary 
      tract cancer: Result from three cohorts.
PG  - 942-949
LID - 10.1002/ijc.34572 [doi]
AB  - Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was 
      associated with an increased risk of biliary tract cancer (BTC), however, 
      confounders were not adequately controlled. Our study aimed to evaluate PPI use 
      and subsequent risk of BTC and its subtypes in three well-established cohorts. We 
      conducted a pooled analysis of the subjects free of cancers in UK Biobank 
      (n = 463 643), Nurses' Health Study (NHS, n = 80 235) and NHS II (n = 95 869). 
      Propensity score weighted Cox models were used to estimate marginal HRs of PPIs 
      use on BTC risk, accounting for potential confounders. We documented 284 BTC 
      cases in UK Biobank (median follow-up: 7.6 years), and 91 cases in NHS and NHS II 
      cohorts (median follow-up: 15.8 years). In UK biobank, PPI users had a 96% higher 
      risk of BTC compared to nonusers in crude model (HR 1.96, 95% CI 1.44-2.66), but 
      the effect was attenuated to null after adjusting for potential confounders (HR 
      0.95, 95% CI 0.60-1.49). PPI use was not associated with risk of BTC in the 
      pooled analysis of three cohorts (HR 0.93, 95% CI 0.60-1.43). We also observed no 
      associations between PPI use with risk of intrahepatic (HR 1.00, 95% CI 
      0.49-2.04), extrahepatic bile duct (HR 1.09, 95% CI 0.52-2.27) and gallbladder 
      cancers (HR 0.66, 95% CI 0.26-1.66) in UK Biobank. In summary, regular use of 
      PPIs was not associated with the risk of BTC and its subtypes.
CI  - (c) 2023 UICC.
FAU - He, Qiangsheng
AU  - He Q
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
AD  - Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen 
      University, Shenzhen, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Huang, Chongfei
AU  - Huang C
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Qin, Xiwen
AU  - Qin X
AD  - Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical 
      Science, Monash University, Melbourne, Australia.
AD  - Victorian Heart Institute, Monash University, Melbourne, Australia.
AD  - Laboratory of Data Discovery for Health (D24H), The University of Hong Kong, 
      Pokfulam, Hong Kong.
FAU - Yu, Yuanyuan
AU  - Yu Y
AD  - Department of surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.
FAU - Tang, Di
AU  - Tang D
AD  - Department of surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 
      Shenzhen, Guangdong, China.
FAU - Huang, Junjie
AU  - Huang J
AUID- ORCID: 0000-0003-2382-4443
AD  - JC School of Public Health and Primary Care, The Chinese University of Hong Kong, 
      Shatin, Hong Kong.
FAU - Kuo, Zi Chong
AU  - Kuo ZC
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Ling, Yuyao
AU  - Ling Y
AD  - School of Clinical Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.
FAU - Mao, Deli
AU  - Mao D
AUID- ORCID: 0000-0001-5430-0883
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Xia, Bin
AU  - Xia B
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
AD  - Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen 
      University, Shenzhen, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Li, Wenjing
AU  - Li W
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
FAU - Lu, Kuiqing
AU  - Lu K
AD  - Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen 
      University, Shenzhen, Guangdong, China.
FAU - Yang, Man
AU  - Yang M
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - He, Yulong
AU  - He Y
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Meng, Wenbo
AU  - Meng W
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu, China.
FAU - Yuan, Jinqiu
AU  - Yuan J
AUID- ORCID: 0000-0003-0016-776X
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
AD  - Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen 
      University, Shenzhen, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
FAU - Pan, Yihang
AU  - Pan Y
AD  - Big Data Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Gastroenterology, Center for Digestive 
      Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 
      Guangdong, China.
LA  - eng
GR  - U01 CA176726/CA/NCI NIH HHS/United States
GR  - UM1 CA186107/CA/NCI NIH HHS/United States
GR  - U01 CA176726/CA/NCI NIH HHS/United States
GR  - UM1 CA186107/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20230526
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Risk Factors
MH  - Prospective Studies
MH  - Incidence
MH  - *Biliary Tract Neoplasms/chemically induced/epidemiology
OTO - NOTNLM
OT  - Nurses' Health Study
OT  - UK Biobank
OT  - biliary tract cancer
OT  - proton pump inhibitor
EDAT- 2023/05/26 06:42
MHDA- 2023/07/17 06:42
CRDT- 2023/05/26 03:59
PHST- 2023/04/17 00:00 [revised]
PHST- 2023/01/18 00:00 [received]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/05/26 06:42 [pubmed]
PHST- 2023/05/26 03:59 [entrez]
AID - 10.1002/ijc.34572 [doi]
PST - ppublish
SO  - Int J Cancer. 2023 Sep 1;153(5):942-949. doi: 10.1002/ijc.34572. Epub 2023 May 
      26.