PMID- 37233914
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20230825
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 22
IP  - 3
DP  - 2023 Sep
TI  - The association between triglyceride-glucose index and hyperferritinemia in 
      patients with type 2 diabetes mellitus.
PG  - 403-412
LID - 10.1007/s42000-023-00453-7 [doi]
AB  - PURPOSE: To investigate the relationship between the triglyceride-glucose (TyG) 
      index and serum ferritin (SF) levels in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: A total of 881 T2DM patients were divided into T(1)(TyG 
      index < 1.66), T(2) (1.66 </= TyG index < 2.21), and T(3) (TyG index >/= 2.21) groups 
      according to the tertiles of the TyG index. The differences in SF levels and the 
      prevalence of hyperferritinemia (SF >/= 300 ng/mL for male or SF >/= 150 ng/mL for 
      female) were compared. The independent correlations between the TyG index and SF, 
      and between hyperferritinemia and TyG in T2DM patients were analyzed, 
      respectively. RESULTS: SF levels in male T2DM patients were higher in the T(3) 
      group (250.12 ng/mL) than in the T(1) and T(2) groups (180.45 and 196.56 ng/mL, 
      both p < 0.01),while in female patients with T2DM,SF levels were higher in the 
      T(3) group (157.25 ng/mL) than in the T(1) group (111.06 ng/mL, p < 0.05).The 
      prevalence of hyperferritinemia in male T2DM patients was higher in the T(3) 
      group (31.3%) than those in the T(1) and T(2) groups (10.4% and 17.3%, both 
      p < 0.05).The TyG index was positively correlated with SF levels in T2DM patients 
      (R = 0.178, p < 0.001).TyG index was independently and positively correlated with 
      SF levels after adjusting for confounders (beta = 0.097, 95%CI [2.870,38.148], 
      p = 0.023).The TyG index was positively independently correlated with 
      hyperferritinemia in male T2DM patients (OR = 1.651, 95%CI [1.120,2.432], 
      p = 0.011). CONCLUSIONS: In parallel with increasing TyG index SF levels 
      gradually increased. The TyG index was positively correlated with SF levels in 
      patients with T2DM and was positively correlated with hyperferritinemia in male 
      T2DM patients.
CI  - (c) 2023. The Author(s), under exclusive licence to Hellenic Endocrine Society.
FAU - Zhao, Yangting
AU  - Zhao Y
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Lv, Xiaoyu
AU  - Lv X
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Chen, Chongyang
AU  - Chen C
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Li, Kai
AU  - Li K
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Wang, Yawen
AU  - Wang Y
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Liu, Jingfang
AU  - Liu J
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China. 
      ljf824168@126.com.
AD  - Department of Endocrinology, the First Hospital of Lanzhou University, Donggang 
      West Road, Lanzhou, Gansu, 730000, People's Republic of China. ljf824168@126.com.
LA  - eng
GR  - No.81960155/National Natural Science Foundation of China/
GR  - 20JR10RA690/Natural Science Foundation of Gansu Province/
GR  - No. GSWSKY-2019-07/Health and Family Planning Commission of Gansu/
PT  - Journal Article
DEP - 20230526
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glucose
MH  - Risk Factors
MH  - Blood Glucose
MH  - Triglycerides
MH  - *Hyperferritinemia
OTO - NOTNLM
OT  - Glucolipid metabolism
OT  - Hyperferritinemia
OT  - Serum ferritin
OT  - Triglyceride-glucose index
OT  - Type 2 diabetes mellitus
EDAT- 2023/05/26 13:09
MHDA- 2023/08/25 06:42
CRDT- 2023/05/26 11:12
PHST- 2022/10/13 00:00 [received]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/05/26 13:09 [pubmed]
PHST- 2023/05/26 11:12 [entrez]
AID - 10.1007/s42000-023-00453-7 [pii]
AID - 10.1007/s42000-023-00453-7 [doi]
PST - ppublish
SO  - Hormones (Athens). 2023 Sep;22(3):403-412. doi: 10.1007/s42000-023-00453-7. Epub 
      2023 May 26.