PMID- 37234182
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 38
IP  - 3
DP  - 2023 Jul
TI  - The KL genetic polymorphisms Associated with type 2 diabetes Mellitus.
PG  - 385-392
LID - 10.1007/s12291-022-01057-5 [doi]
AB  - Growing number of research studies have shown that an anti-ageing gene Klotho 
      (KL) is closely associated with Type 2 Diabetes Mellitus (T2DM). In this study, 
      the association is genetically analyzed with single nucleotide polymorphism (SNP) 
      of KL found in T2DM case of an Asian cohort. KL SNP information was obtained from 
      a big database of the Korean Association Resource (KARE) from which 20 KL SNPs 
      were available. Statistical analyses were conducted based on the 3 genetic 
      models, such as additive, dominant, and recessive. Of the 20 KL SNPs, 12 SNPs 
      were found to be significantly associated with T2DM in both of additive and 
      dominant models. Odds ratios of the KL SNPs indicate increased susceptibility to 
      T2DM in additive and dominant models. Significant association of KL with T2DM was 
      further analyzed using imputed KL SNPs from HapMap reference data of the Eastern 
      population. The statistically significant KL SNPs including the imputed SNPs 
      distributed evenly over the KL gene area. The results in this study suggest 
      klotho is a major player in the development of T2DM and the KL SNPs found in the 
      case could be a risk marker of T2DM in the cohort.
CI  - (c) The Author(s), under exclusive licence to Association of Clinical Biochemists 
      of India 2022.
FAU - Jin, Hyun-Seok
AU  - Jin HS
AUID- ORCID: 0000-0002-3673-9806
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, 31499 Asan, Chungnam Republic of Korea. GRID: grid.412238.e. 
      ISNI: 0000 0004 0532 7053
FAU - Jung, Dongju
AU  - Jung D
AUID- ORCID: 0000-0001-6538-2925
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, 31499 Asan, Chungnam Republic of Korea. GRID: grid.412238.e. 
      ISNI: 0000 0004 0532 7053
AD  - Klotho Sciences Corporation, Healthcare Innovation Park, Seoul National 
      University Bundang Hospital Complex, Seongnam, Gyenggi Republic of Korea. GRID: 
      grid.412480.b. ISNI: 0000 0004 0647 3378
LA  - eng
PT  - Journal Article
DEP - 20220810
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC10205947
OTO - NOTNLM
OT  - Cohort studies
OT  - Diabetes Mellitus Type 2
OT  - Polymorphism, single nucleotide
COIS- Conflict of interestThe authors have no competing interests to declare that are 
      relevant to the content of this article.
EDAT- 2023/05/26 13:09
MHDA- 2023/05/26 13:10
PMCR- 2024/07/01
CRDT- 2023/05/26 12:06
PHST- 2022/01/24 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2024/07/01 00:00 [pmc-release]
PHST- 2023/05/26 13:10 [medline]
PHST- 2023/05/26 13:09 [pubmed]
PHST- 2023/05/26 12:06 [entrez]
AID - 1057 [pii]
AID - 10.1007/s12291-022-01057-5 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2023 Jul;38(3):385-392. doi: 10.1007/s12291-022-01057-5. 
      Epub 2022 Aug 10.