PMID- 37236555 OWN - NLM STAT- MEDLINE DCOM- 20230619 LR - 20230619 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 242 IP - Pt 3 DP - 2023 Jul 1 TI - Development of shelf life-extending packaging for vitamin C syrup based on high-density polyethylene and extracted lignin argan shells. PG - 125077 LID - S0141-8130(23)01971-2 [pii] LID - 10.1016/j.ijbiomac.2023.125077 [doi] AB - Biobased packaging is an essential parameter in the pharmaceutical industry. In the present work, bio-composites consisting of high-density polyethylene (HDPE) as a matrix and lignin recovered from argan nut shells as filler were developed to investigate their potential use as packaging materials for vitamin C drugs. The lignin was extracted via alkali and klason processes, and the effects of the extraction method as well as the lignin content on the thermal, morphological, mechanical, and rheological properties of the produced composites, as well as their application for vitamin C packaging, were investigated. Among all the prepared packaging materials, the one with desirable results in pH, color stability, hardness, and mechanical characteristics was based on alkali lignin. It achieved its highest Young's modulus enhancement, 10.12 %, at 10 % alkali lignin loading, while the highest yield strain enhancement (4.65 %) was obtained with 2 % loading. When compared to neat HDPE and HDPE/klason lignin packaging materials, vitamin C solutions packed with this composite showed a lower oxidation rate, attributed to the extremely low pH variation and high color stability of the material, which decreased the rate of vitamin C degradation. According to these findings, HDPE/alkali lignin composite is a promising vitamin C syrup packaging material. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Dghoughi, Asmaa AU - Dghoughi A AD - Laboratory of Mechanics and Materials (LMM), Faculty of Science, Mohammed V-University in Rabat, Morocco; Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. FAU - Nazih, Fatima-Ezzahra AU - Nazih FE AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. FAU - Halloub, Abdellah AU - Halloub A AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; University Mohammed V in Rabat, Faculty of Science, Nanotechnology and Environment Materials Laboratory in Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. FAU - Raji, Marya AU - Raji M AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. Electronic address: m.raji@mascir.ma. FAU - Essabir, Hamid AU - Essabir H AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mechanic, Materials, and Composites (MMC), Laboratory of Energy Engineering, Materials and Systems, National School of Applied Sciences of Agadir, Ibn Zohr University, Agadir 80000, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. FAU - Bensalah, Mohammed Ouadi AU - Bensalah MO AD - Laboratory of Mechanics and Materials (LMM), Faculty of Science, Mohammed V-University in Rabat, Morocco. FAU - Bouhfid, Rachid AU - Bouhfid R AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. FAU - Qaiss, Abou El Kacem AU - Qaiss AEK AD - Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. Electronic address: a.qaiss@mascir.ma. LA - eng PT - Journal Article DEP - 20230524 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 9002-88-4 (Polyethylene) RN - 9005-53-2 (Lignin) RN - PQ6CK8PD0R (Ascorbic Acid) RN - 0 (Vitamins) SB - IM MH - *Polyethylene/chemistry MH - *Lignin/chemistry MH - Ascorbic Acid MH - Vitamins MH - Product Packaging OTO - NOTNLM OT - Argan shell lignin OT - Color stability OT - Drug packaging OT - Shelf life-extending OT - Vitamin C COIS- Declaration of competing interest The authors declare that they have no significant competing financial, professional, or personal interests that might have influenced the performance or presentation of the work described in this manuscript. EDAT- 2023/05/27 09:42 MHDA- 2023/06/19 13:08 CRDT- 2023/05/26 19:29 PHST- 2023/03/16 00:00 [received] PHST- 2023/05/11 00:00 [revised] PHST- 2023/05/22 00:00 [accepted] PHST- 2023/06/19 13:08 [medline] PHST- 2023/05/27 09:42 [pubmed] PHST- 2023/05/26 19:29 [entrez] AID - S0141-8130(23)01971-2 [pii] AID - 10.1016/j.ijbiomac.2023.125077 [doi] PST - ppublish SO - Int J Biol Macromol. 2023 Jul 1;242(Pt 3):125077. doi: 10.1016/j.ijbiomac.2023.125077. Epub 2023 May 24.