PMID- 37236560
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 243
DP  - 2023 Jul 15
TI  - Nano crystalline cellulose based drug delivery system for some non-steroidal 
      anti-inflammatory drugs: Synthesis, characterization and in-vitro simulation 
      studies.
PG  - 124983
LID - S0141-8130(23)01877-9 [pii]
LID - 10.1016/j.ijbiomac.2023.124983 [doi]
AB  - Nano crystalline cellulose (NCC) created a breakthrough in biomedical field 
      because of its important characteristics like large surface area, good mechanical 
      strength, biocompatibility, renewability and feasibility of incorporation to both 
      hydrophilic and hydrophobic substances. In the present study NCC based drug 
      delivery systems (DDSs) of some non-steroidal anti-inflammatory drugs (NSAIDs) 
      were obtained by covalent bonding between hydroxyl groups of NCC with carboxyl 
      group of NSAIDs. Developed DDSs were characterized by means of FT-IR, XRD, SEM 
      and thermal analysis. In-vitro release study and fluorescence study showed that 
      these systems are stable up to 18 h in upper gastrointestinal (GI) tract at 
      pH 1.2 and released NSAIDs in sustained manner over the period of 3 h in 
      intestine at pH 6.8-7.4. Present study performed with the aim to reuse bio-waste 
      even in the form of DDSs is of greater therapeutic efficacy with reduced dosing 
      frequency that overcome physiological adversities involved with NSAIDs.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Gupta, Renu D
AU  - Gupta RD
AD  - Chemistry Department, Kurukshetra University, Kurukshetra 136 119, Haryana, 
      India.
FAU - Raghav, N
AU  - Raghav N
AD  - Chemistry Department, Kurukshetra University, Kurukshetra 136 119, Haryana, 
      India. Electronic address: nraghav.chem@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230524
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 9004-34-6 (Cellulose)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - *Cellulose/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - *Drug Delivery Systems
MH  - Anti-Inflammatory Agents, Non-Steroidal/chemistry
OTO - NOTNLM
OT  - Covalent bonding
OT  - DDS
OT  - Nano cellulose
COIS- Declaration of competing interest The authors has not any conflicts of interests.
EDAT- 2023/05/27 09:42
MHDA- 2023/06/19 13:08
CRDT- 2023/05/26 19:29
PHST- 2022/12/29 00:00 [received]
PHST- 2023/05/15 00:00 [revised]
PHST- 2023/05/18 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/26 19:29 [entrez]
AID - S0141-8130(23)01877-9 [pii]
AID - 10.1016/j.ijbiomac.2023.124983 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2023 Jul 15;243:124983. doi: 10.1016/j.ijbiomac.2023.124983. 
      Epub 2023 May 24.