PMID- 37236562
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 243
DP  - 2023 Jul 15
TI  - Photo-crosslinkable hyaluronic acid microgels with reactive oxygen species 
      scavenging capacity for mesenchymal stem cell encapsulation.
PG  - 124971
LID - S0141-8130(23)01865-2 [pii]
LID - 10.1016/j.ijbiomac.2023.124971 [doi]
AB  - Mesenchymal stem cells (MSCs) have gained increasing attention in various 
      biomedical applications. However, conventional therapeutic approaches, such as 
      direct intravenous injection, are associated with low cell survival due to the 
      shear force during injection and the oxidative stress microenvironments in the 
      lesion area. Herein, a photo-crosslinkable antioxidant hydrogel based on 
      tyramine- and dopamine-modified hyaluronic acid (HA-Tyr/HA-DA) was developed. 
      Meanwhile, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were 
      encapsulated in HA-Tyr/HA-DA hydrogel using a microfluidic system to create 
      size-controllable microgels (hUC-MSCs@microgels). The HA-Tyr/HA-DA hydrogel was 
      demonstrated to have good rheology, biocompatibility, and antioxidant properties 
      for cell microencapsulation. The hUC-MSCs encapsulated in microgels showed a high 
      viability and a significantly improved the survival rate under oxidative stress 
      conditions. Therefore, the presented work provides a promising platform for MSCs 
      microencapsulation, which may further improve the stem cell-based biomedical 
      applications.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Hao, Shiqi
AU  - Hao S
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China.
FAU - Tian, Chen
AU  - Tian C
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China.
FAU - Bai, Yimeng
AU  - Bai Y
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China.
FAU - Wu, Lihuang
AU  - Wu L
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China.
FAU - Hao, Lili
AU  - Hao L
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China.
FAU - Kuang, Yi
AU  - Kuang Y
AD  - College of Chemical and Materials Engineering, Zhejiang A&F University, Lin'an 
      311300, China.
FAU - Yang, Shengxiang
AU  - Yang S
AD  - College of Chemical and Materials Engineering, Zhejiang A&F University, Lin'an 
      311300, China. Electronic address: shengxiangyang2000@163.com.
FAU - Mao, Hongli
AU  - Mao H
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China; NJTech-BARTY Joint Research Center for Innovative Medical Technology, 
      Nanjing 210000, China. Electronic address: h.mao@njtech.edu.cn.
FAU - Gu, Zhongwei
AU  - Gu Z
AD  - Research Institute for Biomaterials, Tech Institute for Advanced Materials, 
      College of Materials Science and Engineering, Jiangsu Collaborative Innovation 
      Center for Advanced Inorganic Function Composites, Suqian Advanced Materials 
      Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, 
      China; NJTech-BARTY Joint Research Center for Innovative Medical Technology, 
      Nanjing 210000, China.
LA  - eng
PT  - Journal Article
DEP - 20230524
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Microgels)
RN  - 0 (Reactive Oxygen Species)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 0 (Antioxidants)
RN  - 0 (Hydrogels)
SB  - IM
MH  - Humans
MH  - *Microgels
MH  - Reactive Oxygen Species
MH  - Hyaluronic Acid
MH  - Antioxidants
MH  - Hydrogels
MH  - *Mesenchymal Stem Cells
OTO - NOTNLM
OT  - Photo-crosslinkable microgel
OT  - ROS scavenging
OT  - Stem cell encapsulation
COIS- Declaration of competing interest The authors declare that the research was 
      conducted without any commercial or financial relationships that could be 
      construed as a potential conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/06/19 13:09
CRDT- 2023/05/26 19:29
PHST- 2023/01/12 00:00 [received]
PHST- 2023/04/15 00:00 [revised]
PHST- 2023/05/17 00:00 [accepted]
PHST- 2023/06/19 13:09 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/26 19:29 [entrez]
AID - S0141-8130(23)01865-2 [pii]
AID - 10.1016/j.ijbiomac.2023.124971 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2023 Jul 15;243:124971. doi: 10.1016/j.ijbiomac.2023.124971. 
      Epub 2023 May 24.