PMID- 37236763
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230622
IS  - 1557-8925 (Electronic)
IS  - 1054-3589 (Linking)
VI  - 97
DP  - 2023
TI  - Lipid mediators generated by the cytochrome P450-Epoxide hydrolase pathway.
PG  - 327-373
LID - S1054-3589(22)00087-4 [pii]
LID - 10.1016/bs.apha.2022.12.004 [doi]
AB  - The cytochrome P450 (CYP) soluble epoxide hydrolase (sEH) pathway generates a 
      large number of biologically active epoxides and diols from a range of omega-3 and 
      omega-6 polyunsaturated fatty acids (PUFAs). While epoxides of arachidonic acid or 
      epoxyeicosatrienoic acids are probably the best studied of these mediators, 
      epoxides of linoleic acid as well as the fish oils; docosahexaenoic acid and 
      eicosapentaenoic acid have also been attributed signaling actions. Cell and 
      tissue levels of the PUFA epoxides are largely determined by the sEH and in many 
      cases inflammation and chronic diseases, e.g., cardiovascular disease, diabetes 
      and Alzheimer's disease, have been associated with increased sEH expression and 
      the accelerated conversion of PUFA epoxides to their corresponding diols. In low 
      concentrations, the diols act to influence stem and progenitor cells as well as 
      brown adipose tissue but in high concentrations, they tend to have 
      pro-inflammatory and cytotoxic effects that promote disease progression. This 
      review outlines some of the actions to the PUFA epoxides and diols in physiology 
      and pathophysiology as well as the beneficial effects associates with sEH 
      inhibition.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Fromel, Timo
AU  - Fromel T
AD  - Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe 
      University, Frankfurt am Main, Germany.
FAU - Hu, Jiong
AU  - Hu J
AD  - Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe 
      University, Frankfurt am Main, Germany.
FAU - Fleming, Ingrid
AU  - Fleming I
AD  - Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe 
      University, Frankfurt am Main, Germany; German Center of Cardiovascular Research 
      (DZHK), Partner site RheinMain, Frankfurt, Germany. Electronic address: 
      fleming@em.uni-frankfurt.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230119
PL  - United States
TA  - Adv Pharmacol
JT  - Advances in pharmacology (San Diego, Calif.)
JID - 9015397
RN  - EC 3.3.2.- (Epoxide Hydrolases)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Epoxy Compounds)
SB  - IM
MH  - Humans
MH  - *Epoxide Hydrolases/metabolism
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - *Fatty Acids, Omega-3/metabolism
MH  - Signal Transduction
MH  - Epoxy Compounds/metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - DiHOME
OT  - Diabetic retinopathy
OT  - EET
OT  - Linoleic acid
OT  - Polyunsaturated fatty acids
OT  - Soluble epoxide hydrolase
COIS- Conflict of interest There are no conflicts of interest to report.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:42
CRDT- 2023/05/26 20:58
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/26 20:58 [entrez]
AID - S1054-3589(22)00087-4 [pii]
AID - 10.1016/bs.apha.2022.12.004 [doi]
PST - ppublish
SO  - Adv Pharmacol. 2023;97:327-373. doi: 10.1016/bs.apha.2022.12.004. Epub 2023 Jan 
      19.