PMID- 37237010
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230609
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 May 26
TI  - Risk assessment of substance use disorders based on the human leukocyte antigen 
      (HLA).
PG  - 8545
LID - 10.1038/s41598-023-35305-2 [doi]
LID - 8545
AB  - Substance use disorders (SUDs) are common and costly conditions that are 
      partially attributable to genetic factors. In light of immune system influences 
      on neural and behavioral aspects of addiction, the present study evaluated the 
      influence of genes involved in the human immune response, human leukocyte antigen 
      (HLA), on SUDs. We used an immunogenetic epidemiological approach to evaluate 
      associations between the population frequencies of 127 HLA alleles and the 
      population prevalences of six SUDs (alcohol, amphetamine, cannabis, cocaine, 
      opioid, and "other" dependence) in 14 countries of Continental Western Europe to 
      identify immunogenetic profiles of each SUD and evaluate their associations. The 
      findings revealed two primary groupings of SUDs based on their immunogenetic 
      profiles: one group comprised cannabis and cocaine, whereas the other group 
      comprised alcohol, amphetamines, opioids, and "other" dependence. Since each 
      individual possesses 12 HLA alleles, the population HLA-SUD scores were 
      subsequently used to estimate individual risk for each SUD. Overall, the findings 
      highlight similarities and differences in immunogenetic profiles of SUDs that may 
      influence the prevalence and co-occurrence of problematic SUDs and may contribute 
      to assessment of SUD risk of an individual on the basis of their HLA genetic 
      makeup.
CI  - (c) 2023. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - James, Lisa M
AU  - James LM
AD  - The HLA Research Group, Brain Sciences Center (11B), Department of Veterans 
      Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, 
      MN, 55417, USA. lmjames@umn.edu.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. lmjames@umn.edu.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA. lmjames@umn.edu.
FAU - Georgopoulos, Apostolos P
AU  - Georgopoulos AP
AD  - The HLA Research Group, Brain Sciences Center (11B), Department of Veterans 
      Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, 
      MN, 55417, USA.
AD  - Department of Neuroscience, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
AD  - Department of Psychiatry, University of Minnesota Medical School, Minneapolis, 
      MN, 55455, USA.
AD  - Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 
      55455, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230526
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA Antigens)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Humans
MH  - *Substance-Related Disorders/epidemiology/genetics
MH  - *Behavior, Addictive
MH  - Risk Assessment
MH  - HLA Antigens/genetics
MH  - *Cocaine
PMC - PMC10220069
COIS- The authors declare no competing interests.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:41
PMCR- 2023/05/26
CRDT- 2023/05/26 23:18
PHST- 2023/03/13 00:00 [received]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/05/29 06:41 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/26 23:18 [entrez]
PHST- 2023/05/26 00:00 [pmc-release]
AID - 10.1038/s41598-023-35305-2 [pii]
AID - 35305 [pii]
AID - 10.1038/s41598-023-35305-2 [doi]
PST - epublish
SO  - Sci Rep. 2023 May 26;13(1):8545. doi: 10.1038/s41598-023-35305-2.