PMID- 37237696
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230530
IS  - 2306-5354 (Print)
IS  - 2306-5354 (Electronic)
IS  - 2306-5354 (Linking)
VI  - 10
IP  - 5
DP  - 2023 May 22
TI  - Computational Modeling of Diffusion-Based Delamination for Active Implantable 
      Medical Devices.
LID - 10.3390/bioengineering10050625 [doi]
LID - 625
AB  - Delamination at heterogeneous material interfaces is one of the most prominent 
      failure modes in active implantable medical devices (AIMDs). A well-known example 
      of an AIMD is the cochlear implant (CI). In mechanical engineering, a multitude 
      of testing procedures are known whose data can be used for detailed modeling with 
      respect to digital twins. Detailed, complex models for digital twins are still 
      lacking in bioengineering since body fluid infiltration occurs both into the 
      polymer substrate and along the metal-polymer interfaces. For a newly developed 
      test for an AIMD or CI composed of silicone rubber and metal wiring or 
      electrodes, a mathematical model of these mechanisms is presented. It provides a 
      better understanding of the failure mechanisms in such devices and their 
      validation against real-life data. The implementation utilizes COMSOL 
      Multiphysics((R)), consisting of a volume diffusion part and models for interface 
      diffusion (and delamination). For a set of experimental data, the necessary 
      diffusion coefficient could be derived. A subsequent comparison of experimental 
      and modeling results showed a good qualitative and functional match. The 
      delamination model follows a mechanical approach. The results of the interface 
      diffusion model, which follows a substance transport-based approach, show a very 
      good approximation to the results of previous experiments.
FAU - Nguyen, Minh-Hai
AU  - Nguyen MH
AUID- ORCID: 0009-0009-4175-3002
AD  - Department of Otolaryngology and Cluster of Excellence "Hearing4all", Hannover 
      Medical School MHH, 30625 Hannover, Germany.
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
FAU - Onken, Adrian
AU  - Onken A
AD  - Department of Otolaryngology and Cluster of Excellence "Hearing4all", Hannover 
      Medical School MHH, 30625 Hannover, Germany.
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
AD  - Department of Engineering, Jade University of Applied Sciences, 26382 
      Wilhelmshaven, Germany.
FAU - Wulff, Anika
AU  - Wulff A
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
FAU - Foremny, Katharina
AU  - Foremny K
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
FAU - Torgau, Patricia
AU  - Torgau P
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
FAU - Schutte, Helmut
AU  - Schutte H
AD  - Department of Engineering, Jade University of Applied Sciences, 26382 
      Wilhelmshaven, Germany.
FAU - Hild, Sabine
AU  - Hild S
AUID- ORCID: 0000-0001-6099-1924
AD  - Institute of Polymer Chemistry, Johannes Kepler University, 4010 Linz, Austria.
FAU - Doll, Theodor
AU  - Doll T
AD  - Department of Otolaryngology and Cluster of Excellence "Hearing4all", Hannover 
      Medical School MHH, 30625 Hannover, Germany.
AD  - Department of Otolaryngology, Hannover Medical School MHH, Carl-Neuberg-Strasse 1, 
      30625 Hannover, Germany.
AD  - Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, 30625 
      Hannover, Germany.
LA  - eng
GR  - EXC2077/H4A/
GR  - 814654/Medical Device Obligations Taskforce/
PT  - Journal Article
DEP - 20230522
PL  - Switzerland
TA  - Bioengineering (Basel)
JT  - Bioengineering (Basel, Switzerland)
JID - 101676056
PMC - PMC10215766
OTO - NOTNLM
OT  - COMSOL Multiphysics(R)
OT  - active implantable medical devices
OT  - cochlear implant
OT  - interface diffusion
OT  - lifetime prediction
OT  - moving boundary diffusion
OT  - volume diffusion
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:43
MHDA- 2023/05/27 09:44
PMCR- 2023/05/22
CRDT- 2023/05/27 01:01
PHST- 2023/04/03 00:00 [received]
PHST- 2023/05/05 00:00 [revised]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/05/27 09:44 [medline]
PHST- 2023/05/27 09:43 [pubmed]
PHST- 2023/05/27 01:01 [entrez]
PHST- 2023/05/22 00:00 [pmc-release]
AID - bioengineering10050625 [pii]
AID - bioengineering-10-00625 [pii]
AID - 10.3390/bioengineering10050625 [doi]
PST - epublish
SO  - Bioengineering (Basel). 2023 May 22;10(5):625. doi: 
      10.3390/bioengineering10050625.