PMID- 37237890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230530
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 5
DP  - 2023 Apr 28
TI  - Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences 
      Due to Diabetes Mellitus and the Effects of Metformin.
LID - 10.3390/antiox12051024 [doi]
LID - 1024
AB  - Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related 
      and often concomitant pathologies, accompanied by common comorbidities such as 
      hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that 
      trigger CAS, and it can drive the vascular complications in T2DM. Metformin can 
      inhibit oxidative stress, yet its effects have not been studied in the context of 
      CAS. Here, we assessed the global oxidative status in plasma from patients with 
      CAS, both alone and with T2DM (and under treatment with metformin), using 
      multimarker scores of systemic oxidative damage (OxyScore) and antioxidant 
      defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, 
      oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase 
      (XOD) activity. In contrast, the AntioxyScore was determined through the catalase 
      (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant 
      capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to 
      control subjects, probably exceeding their antioxidant capacity. Interestingly, 
      patients with CAS and T2DM displayed less oxidative stress, possibly due to the 
      benefits of their pharmacological therapy (metformin). Thus, reducing oxidative 
      stress or enhancing antioxidant capacity through specific therapies could be a 
      good strategy to manage CAS, focusing on personalized medicine.
FAU - Corbacho-Alonso, Nerea
AU  - Corbacho-Alonso N
AUID- ORCID: 0000-0002-5911-9589
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
FAU - Rodriguez-Sanchez, Elena
AU  - Rodriguez-Sanchez E
AUID- ORCID: 0000-0002-5020-949X
AD  - Cardiorenal Translational Laboratory, Instituto de Investigacion Imas12, Hospital 
      Universitario 12 de Octubre, 28041 Madrid, Spain.
FAU - Sastre-Oliva, Tamara
AU  - Sastre-Oliva T
AUID- ORCID: 0000-0002-2399-2773
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
FAU - Mercado-Garcia, Elisa
AU  - Mercado-Garcia E
AD  - Cardiorenal Translational Laboratory, Instituto de Investigacion Imas12, Hospital 
      Universitario 12 de Octubre, 28041 Madrid, Spain.
FAU - Perales-Sanchez, Ines
AU  - Perales-Sanchez I
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
FAU - Juarez-Alia, Cristina
AU  - Juarez-Alia C
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
FAU - Lopez-Almodovar, Luis F
AU  - Lopez-Almodovar LF
AD  - Cardiac Surgery, Hospital General Universitario de Toledo, SESCAM, 45007 Toledo, 
      Spain.
FAU - Padial, Luis R
AU  - Padial LR
AUID- ORCID: 0000-0002-5783-3922
AD  - Department of Cardiology, Hospital General Universitario de Toledo, SESCAM, 45007 
      Toledo, Spain.
FAU - Tejerina, Teresa
AU  - Tejerina T
AD  - Department of Pharmacology, School of Medicine, Universidad Complutense de 
      Madrid, 28040 Madrid, Spain.
FAU - Mourino-Alvarez, Laura
AU  - Mourino-Alvarez L
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
FAU - Ruiz-Hurtado, Gema
AU  - Ruiz-Hurtado G
AUID- ORCID: 0000-0003-3482-0915
AD  - Cardiorenal Translational Laboratory, Instituto de Investigacion Imas12, Hospital 
      Universitario 12 de Octubre, 28041 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares, 
      CIBER-CV Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
FAU - Barderas, Maria G
AU  - Barderas MG
AUID- ORCID: 0000-0003-4290-4721
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM 
      (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain.
AD  - Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, 
      Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), 45071 
      Toledo, Spain.
LA  - eng
GR  - PI18/00995/Instituto de Salud Carlos III/
GR  - PI21/00384/Instituto de Salud Carlos III/
GR  - PI20/00763/Instituto de Salud Carlos III/
GR  - CPII20/00022/Instituto de Salud Carlos III/
GR  - FI18/00261/Instituto de Salud Carlos III/
GR  - SBPLY/19/180501/000226/Regional Government of Castile-La Mancha/
GR  - SBPLY/21/180501/000078/Regional Government of Castile-La Mancha/
GR  - SBPLY/21/180225/000035/Regional Government of Castile-La Mancha/
PT  - Journal Article
DEP - 20230428
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10215415
OTO - NOTNLM
OT  - antioxidant defense
OT  - calcific aortic stenosis
OT  - diabetes mellitus
OT  - metformin
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/27 09:43
PMCR- 2023/04/28
CRDT- 2023/05/27 01:02
PHST- 2023/03/02 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2023/05/27 09:43 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:02 [entrez]
PHST- 2023/04/28 00:00 [pmc-release]
AID - antiox12051024 [pii]
AID - antioxidants-12-01024 [pii]
AID - 10.3390/antiox12051024 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Apr 28;12(5):1024. doi: 10.3390/antiox12051024.