PMID- 37238165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230530
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 10
DP  - 2023 May 9
TI  - New Concepts for the Diagnosis of Polypoidal Choroidal Vasculopathy.
LID - 10.3390/diagnostics13101680 [doi]
LID - 1680
AB  - Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related 
      macular degeneration (nAMD) that is characterized by a branching neovascular 
      network and polypoidal lesions. It is important to differentiate PCV from typical 
      nAMD as there are differences in treatment response between subtypes. Indocyanine 
      green angiography (ICGA) is the gold standard for diagnosing PCV; however, ICGA 
      is an invasive detection method and impractical for extensive use for regular 
      long-term monitoring. In addition, access to ICGA may be limited in some 
      settings. The purpose of this review is to summarize the utilization of 
      multimodal imaging modalities (color fundus photography, optical coherence 
      tomography (OCT), OCT angiography (OCTA), and fundus autofluorescence (FAF)) in 
      differentiating PCV from typical nAMD and predicting disease activity and 
      prognosis. In particular, OCT shows tremendous potential in diagnosing PCV. 
      Characteristics such as subretinal pigment epithelium (RPE) ring-like lesion, en 
      face OCT-complex RPE elevation, and sharp-peaked pigment epithelial detachment 
      provide high sensitivity and specificity for differentiating PCV from nAMD. With 
      the use of more practical, non-ICGA imaging modalities, the diagnosis of PCV can 
      be more easily made and treatment tailored as necessary for optimal outcomes.
FAU - Zhao, Jinzhi
AU  - Zhao J
AUID- ORCID: 0000-0002-0487-5950
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 
      168751, Singapore.
AD  - Tianjin Medical University Eye Hospital, Tianjin 300392, China.
FAU - Chandrasekaran, Priya R
AU  - Chandrasekaran PR
AUID- ORCID: 0000-0003-2393-1329
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 
      168751, Singapore.
FAU - Cheong, Kai Xiong
AU  - Cheong KX
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 
      168751, Singapore.
FAU - Wong, Mark
AU  - Wong M
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 
      168751, Singapore.
FAU - Teo, Kelvin
AU  - Teo K
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 
      168751, Singapore.
AD  - Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS 
      Medical School, Singapore 169857, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230509
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10216902
OTO - NOTNLM
OT  - OCT
OT  - PCV
OT  - color fundus photograph
OT  - en face OCT-complex RPE elevation
OT  - non-ICGA
OT  - sharp-peaked PED
OT  - sub-RPE ring-like lesion
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/27 09:43
PMCR- 2023/05/09
CRDT- 2023/05/27 01:04
PHST- 2023/04/11 00:00 [received]
PHST- 2023/05/06 00:00 [revised]
PHST- 2023/05/07 00:00 [accepted]
PHST- 2023/05/27 09:43 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:04 [entrez]
PHST- 2023/05/09 00:00 [pmc-release]
AID - diagnostics13101680 [pii]
AID - diagnostics-13-01680 [pii]
AID - 10.3390/diagnostics13101680 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 May 9;13(10):1680. doi: 10.3390/diagnostics13101680.