PMID- 37239388
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230531
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 5
DP  - 2023 Apr 30
TI  - Deciphering the Genetic Code of Autoimmune Kidney Diseases.
LID - 10.3390/genes14051028 [doi]
LID - 1028
AB  - Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, 
      resulting in inflammation and pathological damage to the kidneys. This review 
      focuses on the known genetic associations of the major autoimmune kidney diseases 
      that result in the development of glomerulonephritis: lupus nephritis (LN), 
      anti-neutrophil cytoplasmic associated vasculitis (AAV), anti-glomerular basement 
      disease (also known as Goodpasture's disease), IgA nephropathy (IgAN), and 
      membranous nephritis (MN). Genetic associations with an increased risk of disease 
      are not only associated with polymorphisms in the human leukocyte antigen (HLA) 
      II region, which governs underlying processes in the development of autoimmunity, 
      but are also associated with genes regulating inflammation, such as NFkB, IRF4, 
      and FC gamma receptors (FCGR). Critical genome-wide association studies are discussed 
      both to reveal similarities in gene polymorphisms between autoimmune kidney 
      diseases and to explicate differential risks in different ethnicities. Lastly, we 
      review the role of neutrophil extracellular traps, critical inducers of 
      inflammation in LN, AAV, and anti-GBM disease, where inefficient clearance due to 
      polymorphisms in DNase I and genes that regulate neutrophil extracellular trap 
      production are associated with autoimmune kidney diseases.
FAU - Huang, Stephanie U-Shane
AU  - Huang SU
AUID- ORCID: 0000-0003-1581-160X
AD  - Department of Medicine, Centre for Inflammatory Diseases, Monash University, 
      Clayton, VIC 3168, Australia.
FAU - Kulatunge, Oneli
AU  - Kulatunge O
AD  - Department of Medicine, Centre for Inflammatory Diseases, Monash University, 
      Clayton, VIC 3168, Australia.
FAU - O'Sullivan, Kim Maree
AU  - O'Sullivan KM
AUID- ORCID: 0000-0002-3098-7948
AD  - Department of Medicine, Centre for Inflammatory Diseases, Monash University, 
      Clayton, VIC 3168, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230430
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
SB  - IM
MH  - Humans
MH  - Kidney Glomerulus/pathology
MH  - Genome-Wide Association Study
MH  - *Autoimmune Diseases
MH  - Kidney/pathology
MH  - *Anti-Glomerular Basement Membrane Disease/pathology
MH  - *Kidney Diseases/genetics/pathology
MH  - Inflammation/pathology
MH  - Genetic Code
PMC - PMC10218028
OTO - NOTNLM
OT  - IgA nephropathy anti-glomerular basement disease
OT  - anti-neutrophil cytoplasmic antibody vasculitis
OT  - gene mutations
OT  - glomerulonephritis
OT  - inflammation
OT  - lupus nephritis
OT  - neutrophil extracellular traps
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:42
PMCR- 2023/04/30
CRDT- 2023/05/27 01:10
PHST- 2022/12/23 00:00 [received]
PHST- 2023/04/26 00:00 [revised]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:10 [entrez]
PHST- 2023/04/30 00:00 [pmc-release]
AID - genes14051028 [pii]
AID - genes-14-01028 [pii]
AID - 10.3390/genes14051028 [doi]
PST - epublish
SO  - Genes (Basel). 2023 Apr 30;14(5):1028. doi: 10.3390/genes14051028.