PMID- 37239618
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230613
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 20
IP  - 10
DP  - 2023 May 20
TI  - The Influence of Whey Protein on Muscle Strength, Glycemic Control and Functional 
      Tasks in Older Adults with Type 2 Diabetes Mellitus in a Resistance Exercise 
      Program: Randomized and Triple Blind Clinical Trial.
LID - 10.3390/ijerph20105891 [doi]
LID - 5891
AB  - OBJECTIVES: To evaluate the effect of whey protein (WP) supplementation 
      associated with resistance training (RT) on glycemic control, functional tasks, 
      muscle strength, and body composition in older adults living with type 2 diabetes 
      mellitus (T2DM). Secondly, to evaluate the safety of the protocol for renal 
      function. METHODS: The population comprised twenty-six older men living with T2DM 
      (68.5 +/- 11.5 years old). The participants were randomly assigned to the Protein 
      Group (PG) and the Control Group (CG). The handgrip test and evolution of 
      exercise loads, according to the Omni Resistance Exercise Scale, evaluated muscle 
      strength. Functional tasks were assessed by force platform in three different 
      protocols: Sit-to-Stand, Step/Quick Turn, and Step Up/Over. Body composition was 
      evaluated by bioimpedance and glycemic control and renal function were assessed 
      by biochemical analyses. Both groups performed RT for 12 weeks, twice a week, 
      prioritizing large muscle groups. Protein supplementation was 20 g of whey 
      protein isolate and the CG was supplemented with an isocaloric drink, containing 
      20 g of maltodextrin. RESULTS: There was a significant difference in muscle 
      strength, according to the evolution of the exercise loads, but it was not 
      confirmed in the handgrip test. However, there was no significant difference 
      between the groups, regarding performance in functional tasks, glycemic control, 
      or body composition. Renal function showed no alteration. CONCLUSION: The intake 
      of 20 g of WP in older male adults living with T2DM did not increase the effect 
      of RT on muscle strength, functional tasks, and glycemic control. The 
      intervention was proven safe regarding renal function.
FAU - Soares, Andre Luiz de Seixas
AU  - Soares ALS
AD  - Program in Aging Sciences, Universidade Sao Judas Tadeu (USJT), Sao Paulo 
      03166-000, SP, Brazil.
AD  - Georgia Prevention Institute, Medical College of Georgia, Augusta University, 
      Augusta, GA 30912, USA.
FAU - Machado-Lima, Adriana
AU  - Machado-Lima A
AUID- ORCID: 0000-0002-5741-3418
AD  - Program in Aging Sciences, Universidade Sao Judas Tadeu (USJT), Sao Paulo 
      03166-000, SP, Brazil.
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
FAU - Brech, Guilherme Carlos
AU  - Brech GC
AUID- ORCID: 0000-0002-0403-0632
AD  - Program in Aging Sciences, Universidade Sao Judas Tadeu (USJT), Sao Paulo 
      03166-000, SP, Brazil.
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
FAU - Greve, Julia Maria D'Andrea
AU  - Greve JMD
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
FAU - Dos Santos, Joselma Rodrigues
AU  - Dos Santos JR
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
FAU - Inojossa, Thiago Resende
AU  - Inojossa TR
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
FAU - Rogero, Marcelo Macedo
AU  - Rogero MM
AUID- ORCID: 0000-0003-0517-1645
AD  - Department of Nutrition, Faculty of Public Health, FMSUP, Sao Paulo 01151-000, 
      SP, Brazil.
FAU - Salles, Joao Eduardo Nunes
AU  - Salles JEN
AD  - Department of Internal Medicine, The Discipline of Endocrinology, Santa Casa of 
      Sao Paulo Medical School, Sao Paulo 01224-001, SP, Brazil.
FAU - Santarem-Sobrinho, Jose Maria
AU  - Santarem-Sobrinho JM
AD  - Centro de Estudos em Ciencias da Atividade Fisica-CECAFI-FMUSP, Sao Paulo 
      05403-010, SP, Brazil.
FAU - Davis, Catherine L
AU  - Davis CL
AD  - Georgia Prevention Institute, Medical College of Georgia, Augusta University, 
      Augusta, GA 30912, USA.
FAU - Alonso, Angelica Castilho
AU  - Alonso AC
AUID- ORCID: 0000-0002-9644-5068
AD  - Program in Aging Sciences, Universidade Sao Judas Tadeu (USJT), Sao Paulo 
      03166-000, SP, Brazil.
AD  - Laboratory Study of Movement, Instituto de Ortopedia e Traumatologia do Hospital 
      das Clinicas (IOT-HC), Faculdade de Medicina da Universidade de Sao Paulo 
      (FMUSP), Sao Paulo 05402-000, SP, Brazil.
LA  - eng
SI  - ClinicalTrials.gov/NCT03792646
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20230520
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - Middle Aged
MH  - Aged, 80 and over
MH  - Whey Proteins/therapeutic use
MH  - *Resistance Training/methods
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Hand Strength
MH  - Glycemic Control
MH  - Muscle, Skeletal/physiology
MH  - Double-Blind Method
MH  - Muscle Strength/physiology
MH  - Dietary Supplements
MH  - Body Composition/physiology
PMC - PMC10217832
OTO - NOTNLM
OT  - older adults
OT  - postural balance
OT  - resistance training
OT  - type 2 diabetes
OT  - whey protein
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:41
PMCR- 2023/05/20
CRDT- 2023/05/27 01:12
PHST- 2023/02/24 00:00 [received]
PHST- 2023/04/24 00:00 [revised]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/05/29 06:41 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:12 [entrez]
PHST- 2023/05/20 00:00 [pmc-release]
AID - ijerph20105891 [pii]
AID - ijerph-20-05891 [pii]
AID - 10.3390/ijerph20105891 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2023 May 20;20(10):5891. doi: 
      10.3390/ijerph20105891.