PMID- 37240138
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230529
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 10
DP  - 2023 May 15
TI  - Inflammation: The Link between Neural and Vascular Impairment in the Diabetic 
      Retina and Therapeutic Implications.
LID - 10.3390/ijms24108796 [doi]
LID - 8796
AB  - The etiology of diabetic retinopathy (DR) is complex, multifactorial and 
      compromises all the elements of the retinal neurovascular unit (NVU). This 
      diabetic complication has a chronic low-grade inflammatory component involving 
      multiple inflammatory mediators and adhesion molecules. The diabetic milieu 
      promotes reactive gliosis, pro-inflammatory cytokine production and leukocyte 
      recruitment, which contribute to the disruption of the blood retinal barrier. The 
      understanding and the continuous research of the mechanisms behind the strong 
      inflammatory component of the disease allows the design of new therapeutic 
      strategies to address this unmet medical need. In this context, the aim of this 
      review article is to recapitulate the latest research on the role of inflammation 
      in DR and to discuss the efficacy of currently administered anti-inflammatory 
      treatments and those still under development.
FAU - Ramos, Hugo
AU  - Ramos H
AUID- ORCID: 0000-0001-6443-7576
AD  - Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, 
      Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), 28029 Madrid, 
      Spain.
FAU - Hernandez, Cristina
AU  - Hernandez C
AUID- ORCID: 0000-0002-3109-1721
AD  - Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, 
      Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), 28029 Madrid, 
      Spain.
FAU - Simo, Rafael
AU  - Simo R
AUID- ORCID: 0000-0003-0475-3096
AD  - Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, 
      Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), 28029 Madrid, 
      Spain.
FAU - Simo-Servat, Olga
AU  - Simo-Servat O
AUID- ORCID: 0000-0003-3483-652X
AD  - Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, 
      Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas 
      Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), 28029 Madrid, 
      Spain.
LA  - eng
GR  - ICI20/00129/Instituto de Salud Carlos III/
GR  - PI22/01670/Instituto de Salud Carlos III/
GR  - BES-2017-081690/Ministry of Economy, Industry and Competitiveness/
PT  - Journal Article
PT  - Review
DEP - 20230515
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Humans
MH  - Retina
MH  - *Diabetic Retinopathy/drug therapy
MH  - Inflammation/drug therapy
MH  - Blood-Retinal Barrier
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - *Diabetes Mellitus/drug therapy
PMC - PMC10218195
OTO - NOTNLM
OT  - cytokine
OT  - diabetes
OT  - diabetic retinopathy
OT  - inflammation
OT  - neurovascular unit
OT  - retina
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:42
PMCR- 2023/05/15
CRDT- 2023/05/27 01:15
PHST- 2023/04/06 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:15 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - ijms24108796 [pii]
AID - ijms-24-08796 [pii]
AID - 10.3390/ijms24108796 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 May 15;24(10):8796. doi: 10.3390/ijms24108796.