PMID- 37240215
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230529
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 10
DP  - 2023 May 17
TI  - Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity 
      and Diabetes.
LID - 10.3390/ijms24108870 [doi]
LID - 8870
AB  - To meet the increased need for food and energy because of the economic shift 
      brought about by the Industrial Revolution in the 19th century, there has been an 
      increase in persistent organic pollutants (POPs), atmospheric emissions and 
      metals in the environment. Several studies have reported a relationship between 
      these pollutants and obesity, and diabetes (type 1, type 2 and gestational). All 
      of the major pollutants are considered to be endocrine disruptors because of 
      their interactions with various transcription factors, receptors and tissues that 
      result in alterations of metabolic function. POPs impact adipogenesis, thereby 
      increasing the prevalence of obesity in exposed individuals. Metals impact 
      glucose regulation by disrupting pancreatic beta-cells, causing hyperglycemia and 
      impaired insulin signaling. Additionally, a positive association has been 
      observed between the concentration of endocrine disrupting chemicals (EDCs) in 
      the 12 weeks prior to conception and fasting glucose levels. Here, we evaluate 
      what is currently known regarding the link between environmental pollutants and 
      metabolic disorders. In addition, we indicate where further research is required 
      to improve our understanding of the specific effects of pollutants on these 
      metabolic disorders which would enable implementation of changes to enable their 
      prevention.
FAU - Khalil, William Junior
AU  - Khalil WJ
AD  - School of Medicine, Royal College of Surgeons in Ireland Bahrain, Busaiteen 
      15503, Bahrain.
FAU - Akeblersane, Meriem
AU  - Akeblersane M
AD  - School of Medicine, Royal College of Surgeons in Ireland Bahrain, Busaiteen 
      15503, Bahrain.
FAU - Khan, Ana Saad
AU  - Khan AS
AD  - School of Medicine, Royal College of Surgeons in Ireland Bahrain, Busaiteen 
      15503, Bahrain.
FAU - Moin, Abu Saleh Md
AU  - Moin ASM
AD  - Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen 
      15503, Bahrain.
FAU - Butler, Alexandra E
AU  - Butler AE
AD  - Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen 
      15503, Bahrain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230517
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Environmental Pollutants)
RN  - 0 (Endocrine Disruptors)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus/epidemiology/etiology
MH  - Obesity/epidemiology/etiology
MH  - Environmental Pollution/adverse effects
MH  - *Environmental Pollutants/toxicity
MH  - *Hyperglycemia
MH  - *Endocrine Disruptors/toxicity
PMC - PMC10219141
OTO - NOTNLM
OT  - adipogenesis
OT  - atmospheric pollution
OT  - diabetogenesis
OT  - gestational diabetes
OT  - heavy metals
OT  - metabolic disorders
OT  - obesity
OT  - obesogenic
OT  - persistent organic pollutants
OT  - type 1 diabetes
OT  - type 2 diabetes
COIS- No authors have any conflict of interest or competing interest to declare.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:41
PMCR- 2023/05/17
CRDT- 2023/05/27 01:15
PHST- 2023/03/28 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/05/13 00:00 [accepted]
PHST- 2023/05/29 06:41 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:15 [entrez]
PHST- 2023/05/17 00:00 [pmc-release]
AID - ijms24108870 [pii]
AID - ijms-24-08870 [pii]
AID - 10.3390/ijms24108870 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 May 17;24(10):8870. doi: 10.3390/ijms24108870.