PMID- 37240332
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230529
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 10
DP  - 2023 May 19
TI  - Limited Association between Antibodies to Oxidized Low-Density Lipoprotein and 
      Vascular Affection in Patients with Established Systemic Lupus Erythematosus.
LID - 10.3390/ijms24108987 [doi]
LID - 8987
AB  - Patients with systemic lupus erythematosus (SLE) are at an increased risk of 
      cardiovascular disease. We aimed to evaluate whether antibodies to oxidized 
      low-density lipoprotein (anti-oxLDL) were associated with subclinical 
      atherosclerosis in patients with different SLE phenotypes (lupus nephritis, 
      antiphospholipid syndrome, and skin and joint involvement). Anti-oxLDL was 
      measured by enzyme-linked immunosorbent assay in 60 patients with SLE, 60 healthy 
      controls (HCs) and 30 subjects with anti-neutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). Intima-media thickness (IMT) assessment of 
      vessel walls and plaque occurrence were recorded using high-frequency ultrasound. 
      In the SLE cohort, anti-oxLDL was again assessed in 57 of the 60 individuals 
      approximately 3 years later. The levels of anti-oxLDL in the SLE group (median 
      5829 U/mL) were not significantly different from those in the HCs group (median 
      4568 U/mL), while patients with AAV showed significantly higher levels (median 
      7817 U/mL). The levels did not differ between the SLE subgroups. A significant 
      correlation was found with IMT in the common femoral artery in the SLE cohort, 
      but no association with plaque occurrence was observed. The levels of anti-oxLDL 
      antibodies in the SLE group were significantly higher at inclusion compared to 3 
      years later (median 5707 versus 1503 U/mL, p < 0.0001). Overall, we found no 
      convincing support for strong associations between vascular affection and 
      anti-oxLDL antibodies in SLE.
FAU - Wirestam, Lina
AU  - Wirestam L
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Jonsson, Frida
AU  - Jonsson F
AUID- ORCID: 0000-0002-9032-6033
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Enocsson, Helena
AU  - Enocsson H
AUID- ORCID: 0000-0002-2125-2931
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Svensson, Christina
AU  - Svensson C
AUID- ORCID: 0000-0003-2615-2240
AD  - Department of Clinical Physiology, University Hospital and Department of Health, 
      Medicine and Caring Sciences, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Weiner, Maria
AU  - Weiner M
AD  - Department of Nephrology in Linkoping, Department of Health, Medicine and Caring 
      Sciences, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Wettero, Jonas
AU  - Wettero J
AUID- ORCID: 0000-0002-6916-5490
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Zachrisson, Helene
AU  - Zachrisson H
AD  - Department of Clinical Physiology, University Hospital and Department of Health, 
      Medicine and Caring Sciences, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Eriksson, Per
AU  - Eriksson P
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
FAU - Sjowall, Christopher
AU  - Sjowall C
AUID- ORCID: 0000-0003-0900-2048
AD  - Department of Biomedical and Clinical Sciences, Division of Inflammation and 
      Infection, Linkoping University, SE-581 85 Linkoping, Sweden.
LA  - eng
GR  - R-939149/the Swedish Rheumatism Association/
GR  - ALF Grants/the Region Ostergotland/
GR  - 2022/the Gustafsson Foundation/
GR  - FAI-2020-0663/the King Gustaf V's 80-year Anniversary foundation/
GR  - 2021/the King Gustaf V and Queen Victoria's Freemasons foundation/
PT  - Journal Article
DEP - 20230519
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antibodies)
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - Humans
MH  - Carotid Intima-Media Thickness
MH  - *Lupus Erythematosus, Systemic/complications
MH  - Antibodies
MH  - *Atherosclerosis/complications
MH  - *Plaque, Atherosclerotic/etiology
MH  - Lipoproteins, LDL
MH  - Risk Factors
PMC - PMC10219253
OTO - NOTNLM
OT  - SLE
OT  - anti-oxidized low-density lipoprotein
OT  - biomarkers
OT  - cardiovascular disease
OT  - intima-media thickness
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:42
PMCR- 2023/05/19
CRDT- 2023/05/27 01:16
PHST- 2023/03/31 00:00 [received]
PHST- 2023/05/08 00:00 [revised]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:16 [entrez]
PHST- 2023/05/19 00:00 [pmc-release]
AID - ijms24108987 [pii]
AID - ijms-24-08987 [pii]
AID - 10.3390/ijms24108987 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 May 19;24(10):8987. doi: 10.3390/ijms24108987.