PMID- 37241201
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230529
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 5
DP  - 2023 May 17
TI  - The Associations between Kidney Function and Sexual Dysfunction among Males and 
      Females with Type 2 Diabetes Mellitus.
LID - 10.3390/medicina59050969 [doi]
LID - 969
AB  - Background and Objectives: Diabetic kidney disease (DKD), expressed either as 
      albuminuria, low estimated glomerular filtration rate (eGFR) or both, and sexual 
      dysfunction (SD), are common complications among type 2 diabetes mellitus (T2DM) 
      patients. This study aims to assess whether an association exists between DKD and 
      SD, erectile dysfunction (ED) or female sexual dysfunction (FSD) in a T2DM 
      population. Materials and Methods: A cross-sectional study was designed and 
      conducted among T2DM patients. The presence of SD was assessed using the 
      International Index of Erectile Function and the Female Sexual Function Index 
      questionnaires for males and females, respectively, and patients were evaluated 
      for DKD. Results: Overall, 80 patients, 50 males and 30 females, agreed to 
      participate. Sexual dysfunction was present in 80% of the study population. Among 
      the participants, 45% had DKD, 38.5% had albuminuria and/or proteinuria and 24.1% 
      had an eGFR below 60 mL/min/1.73 m(2). The eGFR was associated with SD, ED and 
      FSD. Moreover, SD and ED were proven as significant determinants for lower eGFR 
      values in multiple linear regression analyses. DKD was associated with lower 
      lubrication scores and eGFR was associated with lower desire, arousal, 
      lubrication and total scores; however, the multivariate linear regression 
      analyses showed no significant associations between them. Older age resulted in 
      significantly lower arousal, lubrication, orgasm and total FSFI scores. 
      Conclusions: SD is commonly encountered in older T2DM patients and DKD affects 
      almost half of them. The eGFR has been significantly associated with SD, ED and 
      FSD, while SD and ED were proven to be significant determinants for the eGFR 
      levels.
FAU - Katsimardou, Alexandra
AU  - Katsimardou A
AUID- ORCID: 0000-0002-9180-6071
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Patoulias, Dimitrios
AU  - Patoulias D
AUID- ORCID: 0000-0002-6899-684X
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Zografou, Ioanna
AU  - Zografou I
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Tegou, Zoi
AU  - Tegou Z
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Imprialos, Konstantinos
AU  - Imprialos K
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Stavropoulos, Konstantinos
AU  - Stavropoulos K
AUID- ORCID: 0000-0002-5549-7048
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Toumpourleka, Maria
AU  - Toumpourleka M
AD  - 3rd Department of Cardiology, Aristotle University of Thessaloniki, General 
      Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Karagiannis, Asterios
AU  - Karagiannis A
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Petidis, Konstantinos
AU  - Petidis K
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
FAU - Doumas, Michael
AU  - Doumas M
AD  - 2nd Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", 54642 Thessaloniki, Greece.
AD  - Veterans Affairs Medical Center, George Washington University, Washington, DC 
      20422, USA.
LA  - eng
PT  - Journal Article
DEP - 20230517
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Aged
MH  - *Diabetes Mellitus, Type 2
MH  - Albuminuria/complications
MH  - Cross-Sectional Studies
MH  - *Sexual Dysfunction, Physiological/etiology/epidemiology
MH  - *Erectile Dysfunction/complications/epidemiology
MH  - Kidney
PMC - PMC10220764
OTO - NOTNLM
OT  - albuminuria
OT  - diabetic kidney disease
OT  - eGFR
OT  - erectile dysfunction
OT  - female sexual dysfunction
OT  - sexual dysfunction
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/29 06:42
PMCR- 2023/05/17
CRDT- 2023/05/27 01:21
PHST- 2023/04/19 00:00 [received]
PHST- 2023/05/04 00:00 [revised]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:21 [entrez]
PHST- 2023/05/17 00:00 [pmc-release]
AID - medicina59050969 [pii]
AID - medicina-59-00969 [pii]
AID - 10.3390/medicina59050969 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 May 17;59(5):969. doi: 10.3390/medicina59050969.