PMID- 37242741
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230530
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 15
IP  - 5
DP  - 2023 May 15
TI  - Current Trends in Gelatin-Based Drug Delivery Systems.
LID - 10.3390/pharmaceutics15051499 [doi]
LID - 1499
AB  - Gelatin is a highly versatile natural polymer, which is widely used in 
      healthcare-related sectors due to its advantageous properties, such as 
      biocompatibility, biodegradability, low-cost, and the availability of exposed 
      chemical groups. In the biomedical field, gelatin is used also as a biomaterial 
      for the development of drug delivery systems (DDSs) due to its applicability to 
      several synthesis techniques. In this review, after a brief overview of its 
      chemical and physical properties, the focus is placed on the commonly used 
      techniques for the development of gelatin-based micro- or nano-sized DDSs. We 
      highlight the potential of gelatin as a carrier of many types of bioactive 
      compounds and its ability to tune and control select drugs' release kinetics. The 
      desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray 
      drying techniques are described from a methodological and mechanistic point of 
      view, with a careful analysis of the effects of the main variable parameters on 
      the DDSs' properties. Lastly, the outcomes of preclinical and clinical studies 
      involving gelatin-based DDSs are thoroughly discussed.
FAU - Milano, Francesca
AU  - Milano F
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
FAU - Masi, Annalia
AU  - Masi A
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
FAU - Madaghiele, Marta
AU  - Madaghiele M
AUID- ORCID: 0000-0003-3039-9107
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
FAU - Sannino, Alessandro
AU  - Sannino A
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
FAU - Salvatore, Luca
AU  - Salvatore L
AUID- ORCID: 0000-0001-6747-2473
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
AD  - Typeone Biomaterials Srl, Via Europa 113, 73021 Calimera, Italy.
FAU - Gallo, Nunzia
AU  - Gallo N
AUID- ORCID: 0000-0003-1810-7917
AD  - Department of Engineering for Innovation, University of Salento, Via Monteroni, 
      73100 Lecce, Italy.
LA  - eng
GR  - B89J20002390009/Regione Puglia/
PT  - Journal Article
PT  - Review
DEP - 20230515
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC10221778
OTO - NOTNLM
OT  - clinical studies
OT  - drug delivery systems
OT  - gelatin
OT  - microparticles
OT  - nanoparticles
COIS- The authors declare no conflict of interest.
EDAT- 2023/05/27 09:42
MHDA- 2023/05/27 09:43
PMCR- 2023/05/15
CRDT- 2023/05/27 01:30
PHST- 2023/04/24 00:00 [received]
PHST- 2023/05/11 00:00 [revised]
PHST- 2023/05/13 00:00 [accepted]
PHST- 2023/05/27 09:43 [medline]
PHST- 2023/05/27 09:42 [pubmed]
PHST- 2023/05/27 01:30 [entrez]
PHST- 2023/05/15 00:00 [pmc-release]
AID - pharmaceutics15051499 [pii]
AID - pharmaceutics-15-01499 [pii]
AID - 10.3390/pharmaceutics15051499 [doi]
PST - epublish
SO  - Pharmaceutics. 2023 May 15;15(5):1499. doi: 10.3390/pharmaceutics15051499.