PMID- 37245063
OWN - NLM
STAT- MEDLINE
DCOM- 20231201
LR  - 20240111
IS  - 1759-4685 (Electronic)
IS  - 1674-2788 (Print)
IS  - 1759-4685 (Linking)
VI  - 15
IP  - 5
DP  - 2023 Nov 27
TI  - Human umbilical cord-derived mesenchymal stem cells alleviate oxidative 
      stress-induced islet impairment via the Nrf2/HO-1 axis.
LID - 10.1093/jmcb/mjad035 [doi]
LID - mjad035
AB  - Hyperglycaemia-induced oxidative stress may disrupt insulin secretion and beta-cell 
      survival in diabetes mellitus by overproducing reactive oxygen species. Human 
      umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit antioxidant 
      properties. However, the mechanisms by which hUC-MSCs protect beta-cells from high 
      glucose-induced oxidative stress remain underexplored. In this study, we showed 
      that intravenously injected hUC-MSCs engrafted into the injured pancreas and 
      promoted pancreatic beta-cell function in a mouse model of type 1 diabetes mellitus. 
      The in vitro study revealed that hUC-MSCs attenuated high glucose-induced 
      oxidative stress and prevented beta-cell impairment via the Nrf2/HO-1 signalling 
      pathway. Nrf2 knockdown partially blocked the anti-oxidative effect of hUC-MSCs, 
      resulting in beta-cell decompensation in a high-glucose environment. Overall, these 
      findings provide novel insights into how hUC-MSCs protect beta-cells from high 
      glucose-induced oxidative stress.
CI  - (c) The Author(s) (2023). Published by Oxford University Press on behalf of Journal 
      of Molecular Cell Biology, CEMCS, CAS.
FAU - Liu, Peng
AU  - Liu P
AD  - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai 
      Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated 
      to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
FAU - Cao, Baige
AU  - Cao B
AD  - Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, 
      School of Medicine, Tongji University, Shanghai 200434, China.
FAU - Zhou, Yang
AU  - Zhou Y
AUID- ORCID: 0000-0002-6967-421X
AD  - Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, 
      School of Medicine, Tongji University, Shanghai 200092, China.
FAU - Zhang, Huina
AU  - Zhang H
AD  - Stem Cell Translational Research Center, Tongji Hospital, School of Medicine, 
      Tongji University, Shanghai 200065, China.
FAU - Wang, Congrong
AU  - Wang C
AD  - Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, 
      School of Medicine, Tongji University, Shanghai 200434, China.
LA  - eng
GR  - 82070913/National Natural Science Foundation of China/
GR  - 20ZR1446000/Shanghai Science and Technology Development Funds/
GR  - sykyqd01801/Shanghai Fourth People's Hospital/
GR  - SHKLD-KF-2101/Shanghai Key Laboratory of Diabetes Mellitus/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Mol Cell Biol
JT  - Journal of molecular cell biology
JID - 101503669
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (NF-E2-Related Factor 2)
RN  - EC 1.14.14.18 (HMOX1 protein, human)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Glucose/metabolism
MH  - *Mesenchymal Stem Cells/metabolism
MH  - *NF-E2-Related Factor 2/metabolism
MH  - Oxidative Stress
MH  - Umbilical Cord
PMC - PMC10681279
OTO - NOTNLM
OT  - Nrf2
OT  - mesenchymal stem cells
OT  - oxidative stress
OT  - type 1 diabetes
OT  - beta-cell protection
EDAT- 2023/05/28 06:41
MHDA- 2023/11/29 06:43
PMCR- 2023/05/27
CRDT- 2023/05/28 00:13
PHST- 2022/05/11 00:00 [received]
PHST- 2023/01/10 00:00 [revised]
PHST- 2023/02/14 00:00 [accepted]
PHST- 2023/11/29 06:43 [medline]
PHST- 2023/05/28 06:41 [pubmed]
PHST- 2023/05/28 00:13 [entrez]
PHST- 2023/05/27 00:00 [pmc-release]
AID - 7181487 [pii]
AID - mjad035 [pii]
AID - 10.1093/jmcb/mjad035 [doi]
PST - ppublish
SO  - J Mol Cell Biol. 2023 Nov 27;15(5):mjad035. doi: 10.1093/jmcb/mjad035.