PMID- 37245629
OWN - NLM
STAT- MEDLINE
DCOM- 20230815
LR  - 20230817
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 138
DP  - 2023 Aug
TI  - Clinicopathologic characterization of hepatocellular adenomas in men: a 
      multicenter experience.
PG  - 24-33
LID - S0046-8177(23)00121-1 [pii]
LID - 10.1016/j.humpath.2023.05.010 [doi]
AB  - Hepatocellular adenomas (HCAs) are benign liver neoplasms which most commonly 
      present in women in their reproductive age. In men, they are rare and have a 
      higher risk of malignant transformation to hepatocellular carcinoma (HCC). Here 
      we present our multicenter experience with HCA in men in the United States. A 
      total of 27 HCA cases were included, with a mean age of presentation of 37 years 
      (range, 9-69 years) and a mean size of 6.8 cm (range, 0.9-18.5 cm). Based on the 
      2019 World Health Organization classification, the most common subtype identified 
      was inflammatory HCA (IHCA; 10 cases, 37.0%) followed by unclassified HCA (UHCA; 
      7 cases, 25.9%), HNF1A-inactivated HCA (H-HCA; 6 cases, 22.2%), 
      beta-catenin-activated IHCA (b-IHCA; 3 cases, 11.1%), and beta-catenin-activated HCA 
      (b-HCA; 1 case, 3.7%). Six additional cases diagnosed as hepatocellular neoplasm 
      of uncertain malignant potential (HUMP) were also included in the study. These 
      cases presented in a mean age of 46 years (range, 17-64 years) and a size of 
      10.8 cm (range, 4.2-16.5 cm). We evaluated the significance of androgen receptor 
      (AR) expression by immunohistochemistry (IHC); of the 16 cases with materials 
      available, 8 were considered positive using the Allred score system (2 IHCA, 
      2 H-HCA, 1 UHCA, and 3 HUMP). Of the total cases, 12 were diagnosed on biopsies, 
      for which follow-up information is available for 7, and none of them show 
      evidence of malignant transformation. Of the 21 resection cases, a concomitant 
      well-differentiated HCC within the same lesion was identified in 5 cases (23.8%), 
      which were diagnosed as HCA (n = 4) or HUMP (n = 1). Overall, 15% of cases in our 
      entire cohort of HCA and HUMP showed concomitant HCC, while none of the 7 biopsy 
      cases showed any malignant transformation on follow-up (range, 22-160 months; 
      mean, 61.8 months).
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Gonzalez, Ivan A
AU  - Gonzalez IA
AD  - Department of Pathology, Yale University, New Haven, CT, 06520, USA.
FAU - Torbenson, Michael
AU  - Torbenson M
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, 55901, USA.
FAU - Sharifai, Nima
AU  - Sharifai N
AD  - Department of Pathology & Immunology, Washington University School of Medicine, 
      St. Louis, MO, 63110, USA.
FAU - Byrnes, Kathleen
AU  - Byrnes K
AD  - Department of Pathology & Immunology, Washington University School of Medicine, 
      St. Louis, MO, 63110, USA.
FAU - Chatterjee, Deyali
AU  - Chatterjee D
AD  - Department of Pathology & Immunology, Washington University School of Medicine, 
      St. Louis, MO, 63110, USA.
FAU - Kakar, Sanjay
AU  - Kakar S
AD  - Department of Pathology, University of California, San Francisco, San Francisco, 
      CA, 94143, USA.
FAU - Yeh, Matthew M
AU  - Yeh MM
AD  - Department of Laboratory Medicine and Pathology, University of Washington School 
      of Medicine, Seattle, WA, 98195, USA.
FAU - Wu, Tsung-Teh
AU  - Wu TT
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, 55901, USA.
FAU - Zhang, Xuchen
AU  - Zhang X
AD  - Department of Pathology, Yale University, New Haven, CT, 06520, USA.
FAU - Jain, Dhanpat
AU  - Jain D
AD  - Department of Pathology, Yale University, New Haven, CT, 06520, USA. Electronic 
      address: dhanpat.jain@yale.edu.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230526
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (beta Catenin)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - *Adenoma, Liver Cell
MH  - *Liver Neoplasms
MH  - *Carcinoma, Hepatocellular
MH  - beta Catenin
MH  - Biopsy
MH  - *Precancerous Conditions
OTO - NOTNLM
OT  - Androgen
OT  - Atypical hepatocellular neoplasm
OT  - Hepatocellular adenoma
OT  - Hepatocellular carcinoma
OT  - Hepatocellular neoplasm
OT  - Men
EDAT- 2023/05/29 00:42
MHDA- 2023/08/15 06:42
CRDT- 2023/05/28 19:24
PHST- 2023/04/13 00:00 [received]
PHST- 2023/05/18 00:00 [revised]
PHST- 2023/05/22 00:00 [accepted]
PHST- 2023/08/15 06:42 [medline]
PHST- 2023/05/29 00:42 [pubmed]
PHST- 2023/05/28 19:24 [entrez]
AID - S0046-8177(23)00121-1 [pii]
AID - 10.1016/j.humpath.2023.05.010 [doi]
PST - ppublish
SO  - Hum Pathol. 2023 Aug;138:24-33. doi: 10.1016/j.humpath.2023.05.010. Epub 2023 May 
      26.