PMID- 37246392
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20230608
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 71
IP  - 22
DP  - 2023 Jun 7
TI  - Development of Magnetic Molecularly Imprinted Polymer Coupled Nanospray Ion 
      Source for Analysis of Cephalosporin Antibiotics in Food Samples.
PG  - 8656-8664
LID - 10.1021/acs.jafc.3c01527 [doi]
AB  - A magnetic molecularly imprinted polymer (MMIP) coupled nanospray ion source was 
      developed for analysis of cephalosporin antibiotics in food samples. MIP coated 
      Fe(3)O(4) nanospheres were prepared for magnetic solid-phase extraction (MSPE) of 
      the antibiotics in the extract of samples and then integrated into the nanospray 
      capillary for further desorption and mass spectrometry analysis. The developed 
      device combines the advantages of high extraction efficiency of MSPE, unique 
      selectivity of MIPs, and fast analysis speed of ambient ionization mass 
      spectrometry (AIMS). Five cephalosporin antibiotics in milk, egg, and beef 
      samples were analyzed using the developed methods. High sensitivities with limits 
      of detection (LODs) from 0.3 to 0.5 mug kg(-1) were achieved for cephalosporin 
      antibiotics in milk, egg, and beef samples, respectively. Good linearity, 
      determination coefficient values (R(2) > 0.992), and precision (RSD < 15%) with 
      recoveries ranging from 72.6% to 115.5% were obtained using the spiked milk, egg, 
      and beef sample matrices.
FAU - Hao, Ya-Xin
AU  - Hao YX
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
AD  - Qilu University of Technology (Shandong Academy of Science), Shandong Analysis 
      and Test Centre, Jinan, Shandong 250014, China.
AD  - Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 
      100176, China.
FAU - Yang, Min-Li
AU  - Yang ML
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
AD  - Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 
      100176, China.
FAU - Chen, Xiang-Feng
AU  - Chen XF
AUID- ORCID: 0000-0001-9266-7707
AD  - Qilu University of Technology (Shandong Academy of Science), Shandong Analysis 
      and Test Centre, Jinan, Shandong 250014, China.
FAU - Zhang, Feng
AU  - Zhang F
AUID- ORCID: 0000-0002-7888-9669
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
AD  - Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 
      100176, China.
FAU - Li, Na
AU  - Li N
AD  - Qilu University of Technology (Shandong Academy of Science), Shandong Analysis 
      and Test Centre, Jinan, Shandong 250014, China.
FAU - He, Mu-Yi
AU  - He MY
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
AD  - Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 
      100176, China.
FAU - Xu, Mei-Xia
AU  - Xu MX
AD  - Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 
      100176, China.
AD  - Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing 
      100176, China.
LA  - eng
PT  - Journal Article
DEP - 20230528
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Cephalosporins)
RN  - 0 (Molecularly Imprinted Polymers)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - *Cephalosporins/analysis
MH  - Molecularly Imprinted Polymers/analysis
MH  - *Molecular Imprinting
MH  - Anti-Bacterial Agents/analysis
MH  - Solid Phase Extraction/methods
MH  - Magnetic Phenomena
MH  - Chromatography, High Pressure Liquid
OTO - NOTNLM
OT  - ambient ionization
OT  - cephalosporin antibiotics
OT  - magnetic molecularly imprinted polymer
OT  - magnetic solid-phase extraction
EDAT- 2023/05/29 06:41
MHDA- 2023/06/08 06:42
CRDT- 2023/05/29 03:42
PHST- 2023/06/08 06:42 [medline]
PHST- 2023/05/29 06:41 [pubmed]
PHST- 2023/05/29 03:42 [entrez]
AID - 10.1021/acs.jafc.3c01527 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2023 Jun 7;71(22):8656-8664. doi: 10.1021/acs.jafc.3c01527. 
      Epub 2023 May 28.