PMID- 37246779
OWN - NLM
STAT- MEDLINE
DCOM- 20230603
LR  - 20230603
IS  - 1735-367X (Electronic)
IS  - 1735-1383 (Linking)
VI  - 20
IP  - 2
DP  - 2023 May 31
TI  - Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances 
      Th2 Cytokines in Experimental Atopic Dermatitis Mice.
PG  - 167-176
LID - 10.22034/iji.2023.97283.2494 [doi]
AB  - BACKGROUND: Molecular markers are involved in atopic dermatitis (AD) 
      pathogenesis. The estrogen receptor (ESR)-1 gene, encoding ERalpha, is reported to 
      express aberrantly in AD patients. OBJECTIVE: To detect the biological functions 
      of ESR1 in 2,4 dinitrochlorobenzene (DNCB)-treated mice. METHODS: The 
      DNCB-treated mice received a topical application of emulsion containing the 
      1,3-bis(4 hydroxyphenyl)-4-methyl-5-[4-(2-piperidinyl ethoxy) phenol]-1H-pyrazole 
      dihydrochloride (MPP; an ESR1-selective antagonist) to dorsal skins and ears. 
      Then the dermatitis scores, histopathological changes, and cytokine levels were 
      evaluated. RESULTS: MPP specifically downregulated ESR1 expression in 
      DNCB-applied mice. Functionally, application of MPP abolished the DNCB-induced 
      promotion in dermatitis score. Additionally, MPP administration protected against 
      DNCB-induced dermatitis severity, suppressed mast cell infiltration and reduced 
      production of immunoglobulin E (IgE) and thymus and activation-regulated 
      chemokine (TARC). Moreover, MPP treatment inhibited DNCB-induced production of 
      Th2 cytokines and infiltration of CD4+ T cells. CONCLUSION: ESR1 facilitates 
      Th2-immune response and enhances Th2 cytokines in AD mice.
FAU - Niu, Jianrong
AU  - Niu J
AUID- ORCID: 0009-0007-9213-7184
AD  - Department of Dermatology, Air Force Medical Center PLA, Beijing 100142, China.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of Dermatology, Air Force Medical Center PLA, Beijing 100142, China.
FAU - Tian, Rong
AU  - Tian R
AUID- ORCID: 0000-0003-4906-8666
AD  - Department of Dermatology, Air Force Medical Center PLA, Beijing 100142, China.
FAU - Wang, Xudong
AU  - Wang X
AD  - Southern Medical District of Chinese PLA General Hospital, Beijing 100853, China.
LA  - eng
PT  - Journal Article
DEP - 20230529
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Esr1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Cytokines/metabolism
MH  - *Dermatitis, Atopic/genetics
MH  - Dinitrochlorobenzene/adverse effects/metabolism
MH  - Estrogen Receptor alpha/genetics/metabolism
MH  - Immunity
MH  - Mice, Inbred BALB C
MH  - Skin/metabolism/pathology
OTO - NOTNLM
OT  - Antagonist
OT  - Atopic Dermatitis
OT  - ESR1
OT  - Inflammatory Cytokines
OT  - Mice
EDAT- 2023/05/29 13:05
MHDA- 2023/06/01 06:42
CRDT- 2023/05/29 07:25
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/05/29 13:05 [pubmed]
PHST- 2023/05/29 07:25 [entrez]
AID - 10.22034/iji.2023.97283.2494 [doi]
PST - ppublish
SO  - Iran J Immunol. 2023 May 31;20(2):167-176. doi: 10.22034/iji.2023.97283.2494. 
      Epub 2023 May 29.