PMID- 37247205
OWN - NLM
STAT- MEDLINE
DCOM- 20230714
LR  - 20230721
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 46
IP  - 7
DP  - 2023 Jul
TI  - The specific value of upgrading to left bundle branch area pacing in patients 
      with pacing-induced cardiomyopathy or non-pacing-induced cardiomyopathy related 
      upgrade status: A retrospective study.
PG  - 761-770
LID - 10.1111/pace.14723 [doi]
AB  - AIMS: Left bundle branch area pacing (LBBaP) upgrade can improve cardiac function 
      and clinical outcomes in patients with pacing-induced cardiomyopathy (PICM), but 
      the specific value of LBBaP upgrade, especially compared with the cardiac 
      function level before right ventricular pacing (RVP) in patients with PICM and 
      non-pacing-induced cardiomyopathy-related upgrade status (Non-PICMUS) is still 
      unknown. METHODS: This study retrospectively enrolled 70 patients with LBBaP 
      upgrade (38 patients with PICM and 32 patients with Non-PICMUS). All upgrade 
      patients experienced three stages: before RVP (Pre-RVP), before LBBaP upgrade 
      (Pre-LBBaP), and after LBBaP upgrade (Post-LBBaP). QRS duration (QRSd), lead 
      parameters, echocardiographic indicators, and clinical outcomes evaluation were 
      recorded at multiple time points. RESULTS: At the follow-up of 12 months, for 
      PICM patients, left ventricular ejection fraction (LVEF) significantly increased 
      from 36.6% +/- 7.2% to 51.3% +/- 8.7% Post-LBBaP (p < .001), and left ventricular 
      end-diastolic diameter (LVEDD) significantly decreased from 61.5 +/- 6.4 mm to 
      55.2 +/- 6.5 mm Post-LBBaP (p < .001), but they both failed to restore the level 
      Pre-RVP (both p < .001). For PICM patients, New York Heart Association (NYHA) 
      classification, the number of moderate-to-severe heart failure (NYHA III-IV), and 
      diuretics using rate after the LBBaP upgrade also could not restore to the level 
      Pre-RVP (all p < .001). At the follow-up of 12 months, Non-PICMUS patients after 
      the LBBaP upgrade had no significant improvement in LVEF, LVEDD, and NYHA 
      classification (all p > .05). CONCLUSION: LBBaP upgrade effectively improved the 
      cardiac function and clinical outcomes in PICM patients, but its effectiveness 
      seemed to be limited as the deteriorated cardiac function cannot be completely 
      reversed. For Non-PICMUS patients, the cardiac function and clinical outcomes 
      Post-LBBaP had no significant improvement.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Shan, Yu
AU  - Shan Y
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Lin, Maoning
AU  - Lin M
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Sun, Yaxun
AU  - Sun Y
AUID- ORCID: 0000-0002-5457-7855
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Zhang, Jiefang
AU  - Zhang J
AUID- ORCID: 0000-0002-0327-1987
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Jiang, Hangpan
AU  - Jiang H
AD  - Department of Cardiology, The Fourth Affiliated Hospital, College of Medicine, 
      Zhejiang University, Yiwu, Zhejiang, China.
FAU - Fu, Guosheng
AU  - Fu G
AUID- ORCID: 0000-0001-7304-7975
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Zhang, Wenbin
AU  - Zhang W
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Wang, Min
AU  - Wang M
AUID- ORCID: 0000-0002-5717-201X
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
LA  - eng
GR  - 81800212/National Natural Science Foundation of China/
GR  - 82070408/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230529
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Cardiac Pacing, Artificial/adverse effects
MH  - Electrocardiography
MH  - *Cardiomyopathies/etiology/therapy
MH  - *Ventricular Septum
MH  - Treatment Outcome
MH  - Bundle of His
OTO - NOTNLM
OT  - cardiac function
OT  - cardiac pacing
OT  - heart failure
OT  - left bundle branch area pacing
OT  - pacing-induced cardiomyopathy
EDAT- 2023/05/29 13:04
MHDA- 2023/07/14 13:07
CRDT- 2023/05/29 11:42
PHST- 2023/04/17 00:00 [revised]
PHST- 2023/02/22 00:00 [received]
PHST- 2023/05/02 00:00 [accepted]
PHST- 2023/07/14 13:07 [medline]
PHST- 2023/05/29 13:04 [pubmed]
PHST- 2023/05/29 11:42 [entrez]
AID - 10.1111/pace.14723 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2023 Jul;46(7):761-770. doi: 10.1111/pace.14723. Epub 
      2023 May 29.