PMID- 37247673
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20230626
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 335
DP  - 2023 Sep
TI  - Associations between exposure to a mixture of perfluoroalkyl and polyfluoroalkyl 
      substances and age at menarche in adolescent girls utilizing three statistical 
      models.
PG  - 139054
LID - S0045-6535(23)01321-8 [pii]
LID - 10.1016/j.chemosphere.2023.139054 [doi]
AB  - Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) is suggested to 
      interfere with endocrine function and may affect female pubertal development. 
      However, the epidemiological evidence on age at menarche associated with PFAS 
      exposure is still inconsistent. Our objective was to investigate association of 
      serum PFAS concentrations with age at menarche among 12-19 years old girls. We 
      used data on 432 girls from National Health and Nutrition Examination Survey 
      (NHANES) 2007-2012 cycles. NHANES reported serum concentrations of 
      perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), 
      perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA) and 
      perfluorodecanoic acid (PFDA) as quantified by liquid chromatography tandem mass 
      spectrometry (LC-MS/MS). Age at menarche was self-reported by girls or their 
      guardians. Multivariable linear regression models were applied to estimate the 
      association of individual PFAS exposure with age at menarche. The combined 
      effects of PFAS mixture exposures on age at menarche were assessed using three 
      statistical methods, including Bayesian kernel machine regression (BKMR), 
      weighted quantile sum regression (WQS), and elastic net regression (ENR). In the 
      single-chemical model, girls in the middle tertile of serum PFOA concentration 
      had a lower age at menarche [regression coefficient (beta) = -0.73 years, 95% 
      confidence interval (CI): -1.44, -0.01; P = 0.047], compared with those in the 
      lower tertile. Girls in the higher tertile of PFNA exposure were associated with 
      older age at menarche (beta = 0.36 years, 95% CI: 0.03, 0.80; P = 0.027), compared 
      with those in the lower tertile. In the multiple-chemical models using BKMR and 
      ENR approaches, higher PFNA exposure was significantly associated with older age 
      at menarche among girls, after adjusting for other PFAS. We found suggestive 
      evidence that higher PFAS mixture exposures may be related to an increase in age 
      at menarche using the BKMR model. In conclusion, exposure to PFNA was associated 
      with the later timing of menarche among girls.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Guo, Menglu
AU  - Guo M
AD  - Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China. Electronic address: guoml@sjtu.edu.cn.
FAU - Yu, Yamei
AU  - Yu Y
AD  - School of Epidemiology and Public Health, Faculty of Medicine, University of 
      Ottawa, Ottawa, Ontario, Canada.
FAU - Liu, Han
AU  - Liu H
AD  - The International Peace Maternity and Child Health Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China.
FAU - Zhu, Changlin
AU  - Zhu C
AD  - Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230527
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 375-95-1 (perfluoro-n-nonanoic acid)
RN  - 0 (Alkanesulfonic Acids)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adolescent
MH  - Child
MH  - Young Adult
MH  - Adult
MH  - Nutrition Surveys
MH  - *Environmental Pollutants
MH  - Menarche
MH  - Bayes Theorem
MH  - Chromatography, Liquid
MH  - Tandem Mass Spectrometry
MH  - *Alkanesulfonic Acids
MH  - *Fluorocarbons
MH  - Models, Statistical
OTO - NOTNLM
OT  - Age at menarche
OT  - Bayesian kernel machine regression (BKMR)
OT  - Elastic net regression (ENR)
OT  - Perfluoroalkyl and polyfluoroalkyl substances
OT  - Weighted quantile sum regression (WQS)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/30 01:06
MHDA- 2023/06/26 06:41
CRDT- 2023/05/29 19:20
PHST- 2023/03/10 00:00 [received]
PHST- 2023/05/25 00:00 [revised]
PHST- 2023/05/26 00:00 [accepted]
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/05/30 01:06 [pubmed]
PHST- 2023/05/29 19:20 [entrez]
AID - S0045-6535(23)01321-8 [pii]
AID - 10.1016/j.chemosphere.2023.139054 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Sep;335:139054. doi: 10.1016/j.chemosphere.2023.139054. Epub 
      2023 May 27.