PMID- 37249455
OWN - NLM
STAT- MEDLINE
DCOM- 20230603
LR  - 20231124
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 67
IP  - 5
DP  - 2023 May 25
TI  - Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against 
      diabetic retinopathy in a Brazilian population.
PG  - e000624
LID - 2359-3997000000624 [pii]
LID - 10.20945/2359-3997000000624 [doi]
LID - e000624
AB  - OBJECTIVE: The objective of this study was to investigate the association between 
      SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). SUBJECTS AND 
      METHODS: This study comprised 603 patients with type 2 diabetes mellitus (T2DM) 
      and DR (cases) and 388 patients with T2DM for more than 10 years and without DR 
      (controls). The TIE2 rs639225 (A/G) and rs638203 (A/G) SNPs and the ANGPT-1 
      rs4324901 (G/T) and rs2507800 (T/A) SNPs were genotyped by real-time PCR using 
      TaqMan MGB probes. RESULTS: The G/G genotype of the rs639225/TIE2, the G/G 
      genotype of the rs638203/ TIE2 and the T allele of the rs4324901/ANGPT-1 SNPs 
      were associated with protection against DR after adjustment for age, glycated 
      hemoglobin, gender, and presence of hypertension (P = 0.042, P = 0.003, and P = 
      0.028, respectively). No association was found between the rs2507800/ANGPT-1 SNP 
      and DR. CONCLUSION: We demonstrated, for the first time, the association of TIE2 
      rs638203 and rsrs939225 SNPs and ANGPT-1 rs4324901 SNP with protection against DR 
      in a Brazilian population.
FAU - Dieter, Cristine
AU  - Dieter C
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
FAU - Lemos, Natalia Emerim
AU  - Lemos NE
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
FAU - de Faria Correa, Nathalia Rodrigues
AU  - de Faria Correa NR
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
FAU - Assmann, Tais Silveira
AU  - Assmann TS
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
FAU - Pellenz, Felipe Mateus
AU  - Pellenz FM
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
FAU - Canani, Luis Henrique
AU  - Canani LH
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
FAU - de Almeida Brondani, Leticia
AU  - de Almeida Brondani L
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
FAU - Bauer, Andrea Carla
AU  - Bauer AC
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil.
AD  - Hospital de Clinicas de Porto Alegre, Divisao de Nefrologia, Porto Alegre, RS, 
      Brasil.
FAU - Crispim, Daisy
AU  - Crispim D
AD  - Hospital de Clinicas de Porto Alegre, Servico de Endocrinologia, Porto Alegre, 
      RS, Brasil.
AD  - Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de 
      Clinica Medica, Programa de Pos-graduacao em Ciencias Medicas: Endocrinologia, 
      Porto Alegre, RS, Brasil, dcmoreira@hcpa.edu.br.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (ANGPT1 protein, human)
RN  - EC 2.7.10.1 (TEK protein, human)
SB  - IM
MH  - Humans
MH  - Brazil
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/genetics/complications
MH  - *Diabetic Retinopathy/genetics
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC10665047
OTO - NOTNLM
OT  - ANGPT-1 gene
OT  - TIE2 gene
OT  - diabetic retinopathy
OT  - polymorphism
OT  - type 2 diabetes mellitus
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2023/05/30 13:07
MHDA- 2023/06/01 06:42
PMCR- 2023/05/29
CRDT- 2023/05/30 10:04
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 10:04 [entrez]
PHST- 2023/05/29 00:00 [pmc-release]
AID - 2359-3997000000624 [pii]
AID - 10.20945/2359-3997000000624 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2023 May 25;67(5):e000624. doi: 
      10.20945/2359-3997000000624.