PMID- 37249921
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 11
IP  - 6
DP  - 2023 Jun
TI  - Rapid onset of effect of benralizumab in a severe eosinophilic and allergic 
      asthma patient with allergic bronchopulmonary aspergillosis.
PG  - e01167
LID - 10.1002/rcr2.1167 [doi]
LID - e01167
AB  - There is limited data on the use of benralizumab in patients with severe asthma, 
      who have allergic bronchopulmonary aspergillosis (ABPA). We report the case of a 
      65-year-old woman with combined severe eosinophilic and allergic asthma, who 
      presented with refractory respiratory symptoms, hypereosinophilia and high 
      immunoglobulin E (IgE) level. The patient had consistently poor Asthma Control 
      Test (ACT) scores, despite a maximum dose of inhalation therapy. Upon further 
      investigations, she was diagnosed with concomitant ABPA. The patient was started 
      on oral prednisolone and itraconazole, but her symptoms persisted. She was then 
      started on subcutaneous omalizumab, but switched to benralizumab after developing 
      a severe allergic reaction. The patient experienced rapid clinical improvements 
      after the first dose of subcutaneous benralizumab. Benralizumab demonstrated a 
      significant role in reducing the exacerbation rate and oral corticosteroid use in 
      this patient, as well as improving lung function, asthma control, and quality of 
      life measures.
CI  - (c) 2023 The Authors. Respirology Case Reports published by John Wiley & Sons 
      Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
FAU - Alaga, Arvindran
AU  - Alaga A
AUID- ORCID: 0000-0003-4873-1999
AD  - Respiratory Department Hospital Sultanah Bahiyah Alor Setar Malaysia.
FAU - Ashraff, Khairil
AU  - Ashraff K
AD  - Respiratory Department Hospital Sultanah Bahiyah Alor Setar Malaysia.
FAU - Din Khan, Nurul Hana
AU  - Din Khan NH
AD  - Respiratory Department Hospital Sultanah Bahiyah Alor Setar Malaysia.
LA  - eng
PT  - Case Reports
DEP - 20230525
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC10209721
OTO - NOTNLM
OT  - allergic asthma
OT  - allergic bronchopulmonary aspergillosis
OT  - benralizumab
OT  - case report
OT  - eosinophilic asthma
COIS- Arvindran Alaga, Khairil Ashraff, and Nurul Hana Din Khan declare no conflict of 
      interest.
EDAT- 2023/05/30 13:07
MHDA- 2023/05/30 13:08
PMCR- 2023/05/25
CRDT- 2023/05/30 11:16
PHST- 2023/01/09 00:00 [received]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/05/30 13:08 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:16 [entrez]
PHST- 2023/05/25 00:00 [pmc-release]
AID - RCR21167 [pii]
AID - 10.1002/rcr2.1167 [doi]
PST - epublish
SO  - Respirol Case Rep. 2023 May 25;11(6):e01167. doi: 10.1002/rcr2.1167. eCollection 
      2023 Jun.