PMID- 37250399
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - Functional-oriented, portable brain-computer interface training for hand motor 
      recovery after stroke: a randomized controlled study.
PG  - 1146146
LID - 10.3389/fnins.2023.1146146 [doi]
LID - 1146146
AB  - BACKGROUND: Brain-computer interfaces (BCIs) have been proven to be effective for 
      hand motor recovery after stroke. Facing kinds of dysfunction of the paretic 
      hand, the motor task of BCIs for hand rehabilitation is relatively single, and 
      the operation of many BCI devices is complex for clinical use. Therefore, we 
      proposed a functional-oriented, portable BCI equipment and explored the 
      efficiency of hand motor recovery after a stroke. MATERIALS AND METHODS: Stroke 
      patients were randomly assigned to the BCI group and the control group. The BCI 
      group received BCI-based grasp/open motor training, while the control group 
      received task-oriented guidance training. Both groups received 20 sessions of 
      motor training in 4 weeks, and each session lasted for 30 min. The Fugl-Meyer 
      assessment of the upper limb (FMA-UE) was applied for the assessment of 
      rehabilitation outcomes, and the EEG signals were obtained for processing. 
      RESULTS: The progress of FMA-UE between the BCI group [10.50 (5.75, 16.50)] and 
      the control group [5.00 (4.00, 8.00)] was significantly different (Z = -2.834, P 
      = 0.005). Meanwhile, the FMA-UE of both groups improved significantly (P < 
      0.001). A total of 24 patients in the BCI group achieved the minimal clinically 
      important difference (MCID) of FMA-UE with an effective rate of 80%, and 16 in 
      the control group achieved the MCID, with an effective rate of 51.6%. The lateral 
      index of the open task in the BCI group was significantly decreased (Z = -2.704, 
      P = 0.007). The average BCI accuracy for 24 stroke patients in 20 sessions was 
      70.7%, which was improved by 5.0% in the final session compared with the first 
      session. CONCLUSION: Targeted hand movement and two motor task modes, namely 
      grasp and open, to be applied in a BCI design may be suitable in stroke patients 
      with hand dysfunction. The functional-oriented, portable BCI training can promote 
      hand recovery after a stroke, and it is expected to be widely used in clinical 
      practice. The lateral index change of inter-hemispheric balance may be the 
      mechanism of motor recovery. TRIAL REGISTRATION NUMBER: ChiCTR2100044492.
CI  - Copyright (c) 2023 Fu, Chen, Shu, Lin, Jiang, Wei, Gao and Jia.
FAU - Fu, Jianghong
AU  - Fu J
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
FAU - Chen, Shugeng
AU  - Chen S
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
FAU - Shu, Xiaokang
AU  - Shu X
AD  - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China.
FAU - Lin, Yifang
AU  - Lin Y
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
FAU - Jiang, Zewu
AU  - Jiang Z
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
FAU - Wei, Dongshuai
AU  - Wei D
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
FAU - Gao, Jiajia
AU  - Gao J
AD  - Department of Rehabilitation Medicine, Shanghai No. 3 Rehabilitation Hospital, 
      Shanghai, China.
FAU - Jia, Jie
AU  - Jia J
AD  - Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 
      Shanghai, China.
AD  - National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan 
      University, Shanghai, China.
AD  - National Center for Neurological Disorders, Huashan Hospital, Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230511
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10213744
OTO - NOTNLM
OT  - RCT
OT  - brain-computer interfaces
OT  - hand rehabilitation
OT  - motor recovery
OT  - stroke
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/30 13:07
MHDA- 2023/05/30 13:08
PMCR- 2023/01/01
CRDT- 2023/05/30 11:23
PHST- 2023/01/17 00:00 [received]
PHST- 2023/04/07 00:00 [accepted]
PHST- 2023/05/30 13:08 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:23 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1146146 [doi]
PST - epublish
SO  - Front Neurosci. 2023 May 11;17:1146146. doi: 10.3389/fnins.2023.1146146. 
      eCollection 2023.