PMID- 37251232
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Role of PGC-1alpha mediated synaptic plasticity, mitochondrial function, and 
      neuroinflammation in the antidepressant effect of Zi-Shui-Qing-Gan-Yin.
PG  - 1108494
LID - 10.3389/fneur.2023.1108494 [doi]
LID - 1108494
AB  - Depression is the most prevalent psychiatric disorder, which needs deeper 
      mechanism research studies and effective therapy. Zi-Shui-Qing-Gan-Yin (ZSQGY) is 
      a traditional Chinese medicine decoction that has been widely used in China in 
      the treatment of depressive symptoms. The aim of the study was to examine the 
      anti-depressive effects of ZSQGY and the possible mechanism of action in the 
      monosodium glutamate (MSG)-induced depressive model and the corticosterone 
      (CORT)-induced PC12 cell model. Liquid chromatography-mass spectrometry (LC-MS) 
      was performed to determine the major compounds in the water extract of ZSQGY. The 
      depressive behaviors were evaluated by the field swimming test (FST), the sucrose 
      preference test (SPT), and the open field test (OFT). Golgi staining and 
      transmission electron microscopy (TEM) were performed to display the alterations 
      of synaptic ultrastructure. The mitochondrion function and inflammatory factors 
      were also quantified. The changes in peroxisome proliferator-activated receptor-gamma 
      co-activator 1alpha (PGC-1alpha) expression were evaluated. The results of this study 
      demonstrated that ZSQGY significantly improved depressive behaviors. ZSQGY also 
      reversed the changes in synaptic plasticity, improved mitochondrion function, and 
      reduced the levels of inflammatory factors. The neuroprotective effects were 
      accompanied by the increased expression of PGC-1alpha. However, the beneficial 
      changes were reversed after the inhibition of PGC-1alpha. These results indicated 
      that ZSQGY effectively could improve depressive behaviors via the mechanisms that 
      regulate synaptic structural plasticity, improve mitochondrion function, and 
      alleviate neuroinflammation, which could, or partly, attribute to the regulation 
      of PGC-1alpha.
CI  - Copyright (c) 2023 Zhu, Zhang, Yang, Cai, Li, Xiang, Xiang, Yang and Cai.
FAU - Zhu, Wen
AU  - Zhu W
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Yang, Feng
AU  - Yang F
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Cai, Min
AU  - Cai M
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Li, Xiangting
AU  - Li X
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Xiang, Yijin
AU  - Xiang Y
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Xiang, Jun
AU  - Xiang J
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Yang, Yunke
AU  - Yang Y
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
FAU - Cai, Dingfang
AU  - Cai D
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
AD  - Laboratory of Neurology, Institute of Integrative Medicine, Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230512
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10213669
OTO - NOTNLM
OT  - PGC-1alpha
OT  - Zi-Shui-Qing-Gan-Yin
OT  - depression
OT  - mitochondrion
OT  - neuroinflammation
OT  - synaptic plasticity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/30 13:07
MHDA- 2023/05/30 13:08
PMCR- 2023/05/12
CRDT- 2023/05/30 11:33
PHST- 2022/11/26 00:00 [received]
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/05/30 13:08 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:33 [entrez]
PHST- 2023/05/12 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1108494 [doi]
PST - epublish
SO  - Front Neurol. 2023 May 12;14:1108494. doi: 10.3389/fneur.2023.1108494. 
      eCollection 2023.