PMID- 37251399
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20231106
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - The role of dendritic cells and their immunometabolism in rheumatoid arthritis.
PG  - 1161148
LID - 10.3389/fimmu.2023.1161148 [doi]
LID - 1161148
AB  - Dendritic cells (DCs) play crucial roles in the pathogenesis of rheumatoid 
      arthritis (RA), a prototypic autoimmune disease characterized by chronic 
      synovitis and joint destruction. Conventional dendritic cells (cDCs) with 
      professional antigen-presenting functions are enriched in the RA synovium. In the 
      synovium, the cDCs are activated and show both enhanced migratory capacities and 
      T cell activation in comparison with peripheral blood cDCs. Plasmacytoid 
      dendritic cells, another subtype of DCs capable of type I interferon production, 
      are likely to be tolerogenic in RA. Monocyte-derived dendritic cells (moDCs), 
      once called "inflammatory DCs", are localized in the RA synovium, and they induce 
      T-helper 17 cell expansion and enhanced proinflammatory cytokine production. 
      Recent studies revealed that synovial proinflammatory hypoxic environments are 
      linked to metabolic reprogramming. Activation of cDCs in the RA synovium is 
      accompanied by enhanced glycolysis and anabolism. In sharp contrast, promoting 
      catabolism can induce tolerogenic DCs from monocytes. Herein, we review recent 
      studies that address the roles of DCs and their immunometabolic features in RA. 
      Immunometabolism of DCs could be a potential therapeutic target in RA.
CI  - Copyright (c) 2023 Suwa, Nagafuchi, Yamada and Fujio.
FAU - Suwa, Yuichi
AU  - Suwa Y
AD  - Department of Allergy and Rheumatology, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
FAU - Nagafuchi, Yasuo
AU  - Nagafuchi Y
AD  - Department of Allergy and Rheumatology, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
AD  - Department of Functional Genomics and Immunological Diseases, Graduate School of 
      Medicine, The University of Tokyo, Tokyo, Japan.
FAU - Yamada, Saeko
AU  - Yamada S
AD  - Department of Allergy and Rheumatology, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
FAU - Fujio, Keishi
AU  - Fujio K
AD  - Department of Allergy and Rheumatology, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230512
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Humans
MH  - *Arthritis, Rheumatoid
MH  - Synovial Membrane
MH  - *Autoimmune Diseases/metabolism
MH  - Monocytes/metabolism
MH  - Dendritic Cells
PMC - PMC10213288
OTO - NOTNLM
OT  - OXPHOS (oxidative phosphorylation)
OT  - dendritic cell (DC)
OT  - glycolysis (glycolytic pathway)
OT  - immunometabolism
OT  - rheumatoid arthritis
COIS- YN belongs to the Social Cooperation Program, Department of functional genomics 
      and immunological diseases, supported by Chugai Pharmaceutical. The remaining 
      authors declare that the research was conducted in the absence of any commercial 
      or financial relationships that could be constructed as a potential conflict of 
      interest.
EDAT- 2023/05/30 13:07
MHDA- 2023/06/01 06:42
PMCR- 2023/01/01
CRDT- 2023/05/30 11:36
PHST- 2023/02/07 00:00 [received]
PHST- 2023/04/28 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:36 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1161148 [doi]
PST - epublish
SO  - Front Immunol. 2023 May 12;14:1161148. doi: 10.3389/fimmu.2023.1161148. 
      eCollection 2023.