PMID- 37251794
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 11
IP  - 5
DP  - 2023 May
TI  - Efficacy of self-assembling peptide in mitigating delayed bleeding after advanced 
      endoscopic resection of gastrointestinal lesions: A meta-analysis.
PG  - E553-E560
LID - 10.1055/a-2057-4505 [doi]
AB  - Background and study aims  Advanced endoscopic resection techniques carry a risk 
      of delayed bleeding (DB). A novel fully synthetic self-assembling peptide (SAP) 
      has shown promising results in mitigating this risk. In this meta-analysis, we 
      evaluated all available data and analyzed the effectiveness of SAP in reducing DB 
      after advanced endoscopic resection of gastrointestinal luminal lesions. Patients 
      and methods  Electronic databases (PubMed, Embase, and Cochrane Library) from 
      January 2010 through October 2022 were searched for publications addressing the 
      use of SAP solution in patients undergoing advanced endoscopic resection of 
      gastrointestinal lesions. Pooled proportions were calculated using fixed (inverse 
      variance) and random-effects (DerSimonian-Laird) models. Results  The initial 
      search identified 277 studies, of which 63 relevant articles were reviewed. The 
      final analysis included data from six studies comprising 307 patients that met 
      inclusion criteria. The pooled rate of DB was 5.73 % (95 % confidence interval 
      [CI] = 3.42-8.59). Mean patient age was 69.40 years +/- 1.82. The weighted mean 
      size of resected lesions was 36.20 mm (95 % CI = 33.37-39.02). Endoscopic 
      submucosal dissection was used in 72.69 % (95 % CI = 67.62-77.48), while 
      endoscopic mucosal resection was used in 26.42 % (95 % CI = 21.69-31.44) of the 
      procedures. Among the 307 patients, 36 % were on antithrombotic medications. No 
      adverse events (AEs) were attributable to using SAP, with a pooled rate of 0.00 % 
      (95 % CI = 0.00-1.49). Conclusions  SAP solution appears promising in reducing 
      post-procedural DB after advanced endoscopic resection of high-risk 
      gastrointestinal lesions with no reported AEs.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Gopakumar, Harishankar
AU  - Gopakumar H
AUID- ORCID: 0000-0002-4921-8794
AD  - Department of Gastroenterology and Hepatology, University of Illinois College of 
      Medicine at Peoria, Peoria, Illinois, United States.
FAU - Vohra, Ishaan
AU  - Vohra I
AUID- ORCID: 0000-0002-9715-8829
AD  - Department of Gastroenterology and Hepatology, University of Illinois College of 
      Medicine at Peoria, Peoria, Illinois, United States.
FAU - Sharma, Neil R
AU  - Sharma NR
AD  - Parkview Cancer Institute, Interventional Oncology & Surgical Endoscopy (IOSE) 
      division, GI Oncology Tumor Site Team, Fort Wayne, Indiana, United States.
FAU - Puli, Srinivas R
AU  - Puli SR
AD  - Department of Gastroenterology and Hepatology, University of Illinois College of 
      Medicine at Peoria, Peoria, Illinois, United States.
LA  - eng
PT  - Journal Article
DEP - 20230526
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC10219783
COIS- Competing interests Dr. Sharma is a consultant for Boston Scientific, Medtronic, 
      Steris, and Olympus.
EDAT- 2023/05/30 13:07
MHDA- 2023/05/30 13:08
PMCR- 2023/05/01
CRDT- 2023/05/30 11:45
PHST- 2022/10/27 00:00 [received]
PHST- 2023/02/22 00:00 [accepted]
PHST- 2023/05/30 13:08 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:45 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - 10.1055/a-2057-4505 [doi]
PST - epublish
SO  - Endosc Int Open. 2023 May 26;11(5):E553-E560. doi: 10.1055/a-2057-4505. 
      eCollection 2023 May.