PMID- 37252008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230531
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Relationship Between Hyperuricemia-Waist Phenotype and Obstructive Sleep Apnea in 
      Type 2 Diabetes Mellitus.
PG  - 1505-1513
LID - 10.2147/DMSO.S408637 [doi]
AB  - OBJECTIVE: This study aimed to propose the hyperuricemia-waist (HUAW) phenotype 
      and investigate the relationship between the HUAW phenotype and obstructive sleep 
      apnea (OSA) in type 2 diabetes mellitus (T2DM). METHODS: We enrolled 255 patients 
      with T2DM (165 male and 90 female) from the First Hospital of Qinhuangdao. The 
      sleep test was performed, and serum uric acid (UA) levels and waist circumference 
      (WC) were calculated. The HUAW phenotype was defined as serum UA concentrations 
      >/=420 mumol/L and WC >/=90 cm (male) and >/=85 cm (female). The participants were 
      categorized into four phenotype groups based on the mentioned cutoffs: normal WC 
      and normal UA concentrations (group A); normal WC and elevated UA concentrations 
      (group B); enlarged WC and normal UA concentrations (group C); and enlarged WC 
      and elevated UA concentrations (group D). Among these participants, 17.6% were 
      characterized by the HUAW phenotype, 80.0% had OSA, and 47.0% had 
      moderate-to-severe OSA. The prevalence of OSA was 43.4%, 71.4%, 89.7%, and 97.8% 
      in groups A, B, C, and D, respectively. The prevalence of moderate-to-severe OSA 
      was 7.5%, 28.6%, 56.9%, and 72.7% in groups A, B, C, and D, respectively. After 
      adjusting for age, sex, duration of diabetes, glycosylated hemoglobin A1c, 
      smoking, and drinking, the HUAW phenotype was found to be significantly 
      associated with OSA and moderate-to-severe OSA. CONCLUSION: The present study 
      proposed the HUAW phenotype and demonstrated that in T2DM, the HUAW phenotype was 
      associated with OSA, especially with moderate-to-severe OSA. Unlike T2DM without 
      the HUAW phenotype, T2DM with the HUAW phenotype showed a significantly higher 
      prevalence of OSA, especially moderate-to-severe OSA. Thus, early sleep studies 
      should be routinely examined in individuals with T2DM who display the HUAW 
      phenotype.
CI  - (c) 2023 Lu and Yin.
FAU - Lu, Na
AU  - Lu N
AD  - Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 
      People's Republic of China.
FAU - Yin, Fuzai
AU  - Yin F
AUID- ORCID: 0000-0003-4982-3318
AD  - Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 
      People's Republic of China.
AD  - Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, 
      Hebei, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230523
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10224684
OTO - NOTNLM
OT  - hyperuricemia
OT  - obstructive sleep apnea
OT  - type 2 diabetes mellitus
OT  - waist circumference
COIS- The authors report no conflicts of interest related to this study.
EDAT- 2023/05/30 13:07
MHDA- 2023/05/30 13:08
PMCR- 2023/05/23
CRDT- 2023/05/30 11:47
PHST- 2023/02/14 00:00 [received]
PHST- 2023/05/18 00:00 [accepted]
PHST- 2023/05/30 13:08 [medline]
PHST- 2023/05/30 13:07 [pubmed]
PHST- 2023/05/30 11:47 [entrez]
PHST- 2023/05/23 00:00 [pmc-release]
AID - 408637 [pii]
AID - 10.2147/DMSO.S408637 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 May 23;16:1505-1513. doi: 10.2147/DMSO.S408637. 
      eCollection 2023.