PMID- 37253422
OWN - NLM
STAT- MEDLINE
DCOM- 20230608
LR  - 20240103
IS  - 1471-2954 (Electronic)
IS  - 0962-8452 (Print)
IS  - 0962-8452 (Linking)
VI  - 290
IP  - 1999
DP  - 2023 May 31
TI  - Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic 
      ruminants.
PG  - 20230538
LID - 10.1098/rspb.2023.0538 [doi]
LID - 20230538
AB  - The muskox and reindeer are the only ruminants that have evolved to survive in 
      harsh Arctic environments. However, the genetic basis of this Arctic adaptation 
      remains largely unclear. Here, we compared a de novo assembled muskox genome with 
      reindeer and other ruminant genomes to identify convergent amino acid 
      substitutions, rapidly evolving genes and positively selected genes among the two 
      Arctic ruminants. We found these candidate genes were mainly involved in brown 
      adipose tissue (BAT) thermogenesis and circadian rhythm. Furthermore, by 
      integrating transcriptomic data from goat adipose tissues (white and brown), we 
      demonstrated that muskox and reindeer may have evolved modulating mitochondrion, 
      lipid metabolism and angiogenesis pathways to enhance BAT thermogenesis. In 
      addition, results from co-immunoprecipitation experiments prove that convergent 
      amino acid substitution of the angiogenesis-related gene hypoxia-inducible factor 
      2alpha (HIF2A), resulting in weakening of its interaction with prolyl hydroxylase 
      domain-containing protein 2 (PHD2), may increase angiogenesis of BAT. Altogether, 
      our work provides new insights into the molecular mechanisms involved in Arctic 
      adaptation.
FAU - Li, Manman
AU  - Li M
AUID- ORCID: 0000-0003-0009-3940
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Li, Xinmei
AU  - Li X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Wu, Zhipei
AU  - Wu Z
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Zhang, Guanghui
AU  - Zhang G
AD  - Key Laboratory of Animal Biotechnology, Ministry of Agriculture and Rural 
      Affairs, Northwest A&F University, Yangling 712100, People's Republic of China.
FAU - Wang, Nini
AU  - Wang N
AUID- ORCID: 0000-0002-3698-5986
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Dou, Mingle
AU  - Dou M
AUID- ORCID: 0000-0003-2590-0649
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Liu, Shanlin
AU  - Liu S
AUID- ORCID: 0000-0001-8118-8313
AD  - Department of Entomology, China Agricultural University, West Yuanmingyuan Road, 
      Beijing 100193, People's Republic of China.
FAU - Yang, Chentao
AU  - Yang C
AUID- ORCID: 0000-0003-3447-2316
AD  - BGI Shenzhen, Shenzhen 518083, People's Republic of China.
FAU - Meng, Guanliang
AU  - Meng G
AUID- ORCID: 0000-0002-6488-1527
AD  - Centre of Taxonomy and Evolutionary Research, Zoological Research Museum 
      Alexander Koenig, 53113 Bonn, Germany.
FAU - Sun, Hailu
AU  - Sun H
AUID- ORCID: 0000-0001-8651-2418
AD  - BGI Shenzhen, Shenzhen 518083, People's Republic of China.
FAU - Hvilsom, Christina
AU  - Hvilsom C
AUID- ORCID: 0000-0001-7870-6888
AD  - Copenhagen Zoo, 2000 Frederiksberg, Denmark.
FAU - Xie, Guoxiang
AU  - Xie G
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Li, Yang
AU  - Li Y
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Li, Zhuo Hui
AU  - Li ZH
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Wang, Wei
AU  - Wang W
AUID- ORCID: 0000-0002-7523-9249
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Jiang, Yu
AU  - Jiang Y
AUID- ORCID: 0000-0003-4821-3585
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
FAU - Heller, Rasmus
AU  - Heller R
AUID- ORCID: 0000-0001-6583-6923
AD  - Section for Computational and RNA Biology, Department of Biology, University of 
      Copenhagen, 2100 Copenhagen, Denmark.
FAU - Wang, Yu
AU  - Wang Y
AUID- ORCID: 0000-0002-0332-6095
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling 
      712100, People's Republic of China.
AD  - Key Laboratory of Animal Biotechnology, Ministry of Agriculture and Rural 
      Affairs, Northwest A&F University, Yangling 712100, People's Republic of China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.c.6644026
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230531
PL  - England
TA  - Proc Biol Sci
JT  - Proceedings. Biological sciences
JID - 101245157
SB  - IM
CIN - Proc Biol Sci. 2024 Jan 10;291(2014):20232448. PMID: 38166424
MH  - Animals
MH  - Adipose Tissue, Brown/metabolism
MH  - *Circadian Rhythm
MH  - Goats
MH  - Reindeer/genetics
MH  - *Ruminants/genetics
MH  - *Thermogenesis/genetics
MH  - Arctic Regions
PMC - PMC10229229
OTO - NOTNLM
OT  - Arctic adaptation
OT  - brown adipose tissue
OT  - comparative genomics
OT  - convergent evolution
OT  - ruminant
COIS- We declare we have no competing interests.
EDAT- 2023/05/31 01:09
MHDA- 2023/06/01 06:42
PMCR- 2024/05/31
CRDT- 2023/05/30 19:13
PHST- 2024/05/31 00:00 [pmc-release]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/05/31 01:09 [pubmed]
PHST- 2023/05/30 19:13 [entrez]
AID - rspb20230538 [pii]
AID - 10.1098/rspb.2023.0538 [doi]
PST - ppublish
SO  - Proc Biol Sci. 2023 May 31;290(1999):20230538. doi: 10.1098/rspb.2023.0538. Epub 
      2023 May 31.