PMID- 37255816
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240423
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Jun
TI  - Role of obesity related inflammation in pathogenesis of peripheral artery disease 
      in patients of type 2 diabetes mellitus.
PG  - 175-188
LID - 10.1007/s40200-023-01221-5 [doi]
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) has emerged as one of the greatest 
      global health challenges of twenty-first century. Visceral obesity is one of the 
      most important determinant of insulin resistance (IR) as well as T2DM 
      complications. Therefore this review focuses on the molecular mechanism of 
      obesity induced inflammation, signaling pathways contributing to diabetes, as 
      well as role of lifestyle interventions and medical therapies in the prevention 
      and management of T2DM. METHOD: Articles were searched on digital data base 
      PubMed, Cochrane Library, and Web of Science. The key words used for search 
      included Type 2 diabetes mellitus, obesity, insulin resistance, vascular 
      inflammation and peripheral arterial disease. RESULT: Visceral obesity is 
      associated with chronic low grade inflammation and activation of immune systems 
      which are involved in pathogenesis of obesity related IR and T2DM. CONCLUSION: 
      Metabolic dysregulation of adipose tissue leads to local hypoxia, 
      misfolded/unfolded protein response and increased circulating free fatty acids, 
      which in turn initiate inflammatory signaling cascades in the population of 
      infiltrating cells. Mechanism that relates the role of adipocytokines with 
      insulin sensitivity and glucose homeostasis might throw a light on the 
      development of therapeutic interventions and subsequently might result in the 
      reduction of vascular complications.
CI  - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 
      2023. Springer Nature or its licensor (e.g. a society or other partner) holds 
      exclusive rights to this article under a publishing agreement with the author(s) 
      or other rightsholder(s); author self-archiving of the accepted manuscript 
      version of this article is solely governed by the terms of such publishing 
      agreement and applicable law.
FAU - Yadav, Umashree
AU  - Yadav U
AD  - Department of Physiology, Institute of Medical Sciences, Banaras Hindu 
      University, Varanasi, Uttar Pradesh 221005 India. GRID: grid.411507.6. ISNI: 0000 
      0001 2287 8816
FAU - Kumar, Nilesh
AU  - Kumar N
AD  - Department of General Medicine, Institute of Medical Sciences, Banaras Hindu 
      University, Varanasi, 221005 India. GRID: grid.411507.6. ISNI: 0000 0001 2287 
      8816
FAU - Sarvottam, Kumar
AU  - Sarvottam K
AUID- ORCID: 0000-0003-1511-2120
AD  - Department of Physiology, Institute of Medical Sciences, Banaras Hindu 
      University, Varanasi, Uttar Pradesh 221005 India. GRID: grid.411507.6. ISNI: 0000 
      0001 2287 8816
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230422
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC10225462
OTO - NOTNLM
OT  - Insulin resistance
OT  - Obesity
OT  - Peripheral arterial disease
OT  - Type 2 diabetes mellitus
OT  - Vascular inflammation
COIS- Conflict of InterestThere is no conflict of Interest.
EDAT- 2023/05/31 13:12
MHDA- 2023/05/31 13:13
PMCR- 2024/04/22
CRDT- 2023/05/31 10:29
PHST- 2023/01/09 00:00 [received]
PHST- 2023/03/29 00:00 [accepted]
PHST- 2023/05/31 13:13 [medline]
PHST- 2023/05/31 13:12 [pubmed]
PHST- 2023/05/31 10:29 [entrez]
PHST- 2024/04/22 00:00 [pmc-release]
AID - 1221 [pii]
AID - 10.1007/s40200-023-01221-5 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2023 Apr 22;22(1):175-188. doi: 
      10.1007/s40200-023-01221-5. eCollection 2023 Jun.