PMID- 37257268
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 100
DP  - 2023 Jun
TI  - Exposure to 3,4-methylenedioxymethamphetamine (MDMA) induced biochemical but not 
      behavioral effects in Daphnia magna.
PG  - 104163
LID - S1382-6689(23)00105-9 [pii]
LID - 10.1016/j.etap.2023.104163 [doi]
AB  - Among amphetamine like stimulants (ATS), the 3,4-methylenedioxymethamphetamine 
      (MDMA) is often detected in sewage and surface waters, representing a potential 
      threat for organisms because of its peculiar mechanism of action (i.e., 
      stimulatory and hallucinogenic). The present study aimed at investigating 
      biochemical (i.e., oxidative stress and energetic biomarkers) and behavioral 
      (i.e., swimming activity) effects induced by a 21-days exposure to two 
      concentrations (50 ng/L and 500 ng/L) of MDMA towards Daphnia magna. The amount 
      of reactive oxygen species (ROS), the activity of antioxidant (SOD, CAT, GPx) and 
      detoxifying (GST) enzymes and lipid peroxidation were measured as oxidative 
      stress-related endpoints. Total energy content was estimated from the measurement 
      of protein, carbohydrate and lipid content to assess energy reserves. The 
      modulation of swimming activity was assessed as behavioral endpoint. Slight 
      effects of MDMA exposure on oxidative stress responses and energy reserves were 
      observed, while no alterations of the swimming behavior was noted.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - De Felice, Beatrice
AU  - De Felice B
AD  - University of Milan, Department of Environmental Science and Policy, Via Celoria 
      26, I-20133 Milan, Italy. Electronic address: beatrice.defelice@unimi.it.
FAU - Parolini, Marco
AU  - Parolini M
AD  - University of Milan, Department of Environmental Science and Policy, Via Celoria 
      26, I-20133 Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230529
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Antioxidants)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - *Daphnia/physiology
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/toxicity/metabolism
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - *Water Pollutants, Chemical/analysis/toxicity
OTO - NOTNLM
OT  - Amphetamine like stimulants
OT  - Illicit drugs
OT  - Oxidative stress
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/01 01:08
MHDA- 2023/06/15 06:42
CRDT- 2023/05/31 18:02
PHST- 2023/02/28 00:00 [received]
PHST- 2023/05/23 00:00 [revised]
PHST- 2023/05/25 00:00 [accepted]
PHST- 2023/06/15 06:42 [medline]
PHST- 2023/06/01 01:08 [pubmed]
PHST- 2023/05/31 18:02 [entrez]
AID - S1382-6689(23)00105-9 [pii]
AID - 10.1016/j.etap.2023.104163 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2023 Jun;100:104163. doi: 10.1016/j.etap.2023.104163. 
      Epub 2023 May 29.