PMID- 37257517
OWN - NLM
STAT- MEDLINE
DCOM- 20230614
LR  - 20230626
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 385
DP  - 2023 Aug 15
TI  - WATCH-DM risk score predicts the prognosis of diabetic phenotype patients with 
      heart failure and preserved ejection fraction.
PG  - 34-40
LID - S0167-5273(23)00738-6 [pii]
LID - 10.1016/j.ijcard.2023.05.045 [doi]
AB  - BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a 
      heterogeneous syndrome. Diabetes may identify an essential phenotype that 
      significantly affects the prognosis of these patients. The WATCH-DM risk score 
      has been validated for predicting the risk of heart failure in outpatients with 
      type 2 diabetes mellitus (T2DM), but its ability to predict clinical outcomes in 
      HFpEF patients with T2DM is unknown. We aimed to assess whether this risk score 
      could predict the prognosis of diabetic phenotype patients with heart failure and 
      preserved ejection fraction. METHODS: We enrolled retrospectively 414 patients 
      with HFpEF (70.03 +/- 8.654 years, 58.70% female), including 203 (49.03%) type 2 
      diabetics. Diabetic HFpEF patients were stratified by baseline WATCH-DM risk 
      score. RESULTS: Diabetic HFpEF patients exhibited a trend toward more concentric 
      remodeling/hypertrophy than nondiabetic HFpEF patients. When analyzed as a 
      continuous variable, per 1-point increase in the WATCH-DM risk score was 
      associated with increased risks of all-cause death (HR 1.181), cardiovascular 
      death (HR 1.239), any hospitalization (HR 1.082), and HF hospitalization (HR 
      1.097). The AUC for the WATCH-DM risk score in predicting incident cardiovascular 
      death (0.7061, 95% CI 0.6329-0.7792) was higher than that of all-cause death, any 
      hospitalization, or HF hospitalization. CONCLUSIONS: As a high-risk phenotype for 
      heart failure, diabetic HFpEF necessitates early risk stratification and specific 
      treatment. To the best of our knowledge, the current study is the first to 
      demonstrate that the WATCH-DM score predicts poor outcomes in diabetic HFpEF 
      patients. Its convenience may allow for quick risk assessments in busy clinical 
      settings.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Zhang, Xinxin
AU  - Zhang X
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Lv, Xin
AU  - Lv X
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Wang, Ning
AU  - Wang N
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Yu, Songqi
AU  - Yu S
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Si, Jinping
AU  - Si J
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Zhang, Yanli
AU  - Zhang Y
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.
FAU - Cai, Mingxu
AU  - Cai M
AD  - Health Management Center, First Affiliated Hospital of Dalian Medical University, 
      Dalian, Liaoning Province 116021, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China. 
      Electronic address: yingliu.med@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230529
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - *Heart Failure
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Stroke Volume
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Prognosis
MH  - Phenotype
MH  - Hospitalization
OTO - NOTNLM
OT  - Heart failure and preserved ejection fraction
OT  - Prognosis
OT  - Risk prediction
OT  - Type 2 diabetes
OT  - WATCH-DM risk score
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interests.
EDAT- 2023/06/01 01:08
MHDA- 2023/06/14 06:42
CRDT- 2023/05/31 19:23
PHST- 2023/03/09 00:00 [received]
PHST- 2023/04/25 00:00 [revised]
PHST- 2023/05/23 00:00 [accepted]
PHST- 2023/06/14 06:42 [medline]
PHST- 2023/06/01 01:08 [pubmed]
PHST- 2023/05/31 19:23 [entrez]
AID - S0167-5273(23)00738-6 [pii]
AID - 10.1016/j.ijcard.2023.05.045 [doi]
PST - ppublish
SO  - Int J Cardiol. 2023 Aug 15;385:34-40. doi: 10.1016/j.ijcard.2023.05.045. Epub 
      2023 May 29.