PMID- 37259417
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230603
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 16
IP  - 2
DP  - 2023 Feb 11
TI  - Ionic Liquids as Tools to Incorporate Pharmaceutical Ingredients into 
      Biopolymer-Based Drug Delivery Systems.
LID - 10.3390/ph16020272 [doi]
LID - 272
AB  - This mini-review focuses on the various roles that ionic liquids (ILs) play in 
      the development and applications of biopolymer-based drug delivery systems 
      (DDSs). Biopolymers are particularly attractive as drug delivery matrices due to 
      their biocompatibility, low immunogenicity, biodegradability, and strength, 
      whereas ILs can assist the formation of drug delivery systems. In this work, we 
      showcase the different strategies that were explored using ILs in 
      biopolymer-based DDSs, including impregnation of active pharmaceutical 
      ingredients (APIs)-ILs into biopolymeric materials, employment of the ILs to 
      simplify the process of making the biopolymer-based DDSs, and using the ILs 
      either as dopants or as anchoring agents.
FAU - Berton, Paula
AU  - Berton P
AUID- ORCID: 0000-0003-4488-6686
AD  - Chemical and Petroleum Engineering Department, University of Calgary, Calgary, AB 
      T2N 1N4, Canada.
FAU - Shamshina, Julia L
AU  - Shamshina JL
AUID- ORCID: 0000-0003-0708-764X
AD  - Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, 
      Texas Tech University, Lubbock, TX 79409, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230211
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC9963465
OTO - NOTNLM
OT  - active pharmaceutical ingredients
OT  - biopolymers
OT  - ionic liquids
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/01 06:42
MHDA- 2023/06/01 06:43
PMCR- 2023/02/11
CRDT- 2023/06/01 01:01
PHST- 2023/01/23 00:00 [received]
PHST- 2023/02/05 00:00 [revised]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/06/01 06:43 [medline]
PHST- 2023/06/01 06:42 [pubmed]
PHST- 2023/06/01 01:01 [entrez]
PHST- 2023/02/11 00:00 [pmc-release]
AID - ph16020272 [pii]
AID - pharmaceuticals-16-00272 [pii]
AID - 10.3390/ph16020272 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2023 Feb 11;16(2):272. doi: 10.3390/ph16020272.