PMID- 37261931
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20231121
IS  - 2379-3694 (Electronic)
IS  - 2379-3694 (Linking)
VI  - 8
IP  - 6
DP  - 2023 Jun 23
TI  - Molecularly Imprinted Chalcone-Branched Polyimide-Based Chemosensors with Stripe 
      Nanopatterns for the Detection of Melittin.
PG  - 2298-2308
LID - 10.1021/acssensors.3c00341 [doi]
AB  - In this study, a chalcone-branched polyimide (CB-PI) was synthesized by the 
      Steglich esterification reaction for selective recognition of the toxic peptide 
      melittin (MEL). MEL was immobilized on a nanopatterned poly(dimethylsiloxane) 
      (PDMS) mold using a conventional surface modification technique to increase 
      binding sites. A stripe-nanopatterned thin CB-PI film was formed on a quartz 
      crystal (QC) substrate by simultaneously performing microcontact printing and 
      ultraviolet (UV) light dimerization using a MEL-immobilized mold. The surface 
      morphology changes and dimensions of the molecularly imprinted polymer (MIP) 
      films with stripe nanopatterns (S-MIP) were analyzed using scanning electron 
      microscopy (SEM) and atomic force microscopy (AFM). The sensing signals (Deltaf and 
      Q(e)) of the S-MIP sensor were investigated upon adsorption in a 100-muL dilute 
      plasma solution containing 30 mug/mL MEL, and its reproducibility, reuse, 
      stability, and durability were investigated. The S-MIP sensor showed high 
      sensitivity (5.49 mL/mg) and coefficient of determination (R(2) = 0.999), and the 
      detection limit (LOD) and the quantification limit (LOQ) were determined as 0.3 
      and 1.1 mug/mL, respectively. In addition, the selectivity coefficients (k*) 
      calculated from the selectivity tests were 2.7-5.7, 2.1-4.3, and 2.8-4.6 for 
      bovine serum albumin (BSA), immunoglobulin G (IgG), and apamin (APA), 
      respectively. Our results indicate that the nanopatterned MIP sensors based on 
      CB-PI demonstrate great potential as a sensing tool for the quantitative analysis 
      of biomolecules.
FAU - Yang, Jin Chul
AU  - Yang JC
AD  - Department of Polymer Science & Engineering, Kyungpook National University, 80 
      Daehak-ro, Daegu 41566, Republic of Korea.
FAU - Lee, Jineun
AU  - Lee J
AUID- ORCID: 0000-0003-3216-0861
AD  - Department of Polymer Science & Engineering, Kyungpook National University, 80 
      Daehak-ro, Daegu 41566, Republic of Korea.
FAU - Lim, Seok Jin
AU  - Lim SJ
AD  - Department of Polymer Science & Engineering, Kyungpook National University, 80 
      Daehak-ro, Daegu 41566, Republic of Korea.
FAU - Kwak, Giseop
AU  - Kwak G
AUID- ORCID: 0000-0003-3111-0918
AD  - Department of Polymer Science & Engineering, Kyungpook National University, 80 
      Daehak-ro, Daegu 41566, Republic of Korea.
FAU - Park, Jinyoung
AU  - Park J
AUID- ORCID: 0000-0003-0261-7605
AD  - Department of Polymer Science & Engineering, Kyungpook National University, 80 
      Daehak-ro, Daegu 41566, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230601
PL  - United States
TA  - ACS Sens
JT  - ACS sensors
JID - 101669031
RN  - 0 (Chalcones)
RN  - 20449-79-0 (Melitten)
RN  - 0 (Polymers)
SB  - IM
MH  - *Molecular Imprinting/methods
MH  - *Chalcones
MH  - Melitten
MH  - Quartz Crystal Microbalance Techniques/methods
MH  - Reproducibility of Results
MH  - Polymers/chemistry
OTO - NOTNLM
OT  - chalcone-branched polyimide
OT  - imprinting factor
OT  - melittin
OT  - molecular imprinting
OT  - photocrosslinking
OT  - quartz crystal microbalance
EDAT- 2023/06/01 23:42
MHDA- 2023/06/26 06:41
CRDT- 2023/06/01 12:13
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/06/01 23:42 [pubmed]
PHST- 2023/06/01 12:13 [entrez]
AID - 10.1021/acssensors.3c00341 [doi]
PST - ppublish
SO  - ACS Sens. 2023 Jun 23;8(6):2298-2308. doi: 10.1021/acssensors.3c00341. Epub 2023 
      Jun 1.